Using a Markov Model and Real-World Evidence to Identify the Most Cost-Effective Cholesterol Treatment Escalation Threshold for the Secondary Prevention of Cardiovascular Disease.

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Title: Using a Markov Model and Real-World Evidence to Identify the Most Cost-Effective Cholesterol Treatment Escalation Threshold for the Secondary Prevention of Cardiovascular Disease.
Authors: Mariani A; Science, Evidence and Analytics Directorate, National Institute for Health and Care Excellence, 2 Redman Place (2nd Floor), London, E20 1JQ, UK. alfredo.mariani@nice.org.uk., Mohiuddin S; Science, Evidence and Analytics Directorate, National Institute for Health and Care Excellence, 2 Redman Place (2nd Floor), London, E20 1JQ, UK., Muller P; Science, Evidence and Analytics Directorate, National Institute for Health and Care Excellence, 2 Redman Place (2nd Floor), London, E20 1JQ, UK., Samarasekera E; Centre for Guidelines, National Institute for Health and Care Excellence, London, UK., Swain SA; Centre for Guidelines, National Institute for Health and Care Excellence, London, UK., Mills J; Liverpool Heart and Chest Hospital, Liverpool, UK., Patel R; Barts Health NHS Trust, University College London Hospitals NHS Foundation Trust, London, UK., Preiss D; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Shantsila E; Institute of Population Health, University of Liverpool, Liverpool, UK., Downing BC; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Lonergan M; Clinical Practice Research Datalink (CPRD), Safety and Surveillance Group, Medicines and Healthcare Products Regulatory Agency, London, UK., Rowark S; Science, Evidence and Analytics Directorate, National Institute for Health and Care Excellence, 2 Redman Place (2nd Floor), London, E20 1JQ, UK., Welton NJ; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Williams R; Clinical Practice Research Datalink (CPRD), Safety and Surveillance Group, Medicines and Healthcare Products Regulatory Agency, London, UK., Wonderling D; Science, Evidence and Analytics Directorate, National Institute for Health and Care Excellence, 2 Redman Place (2nd Floor), London, E20 1JQ, UK.
Source: Applied health economics and health policy [Appl Health Econ Health Policy] 2025 Sep; Vol. 23 (5), pp. 869-883. Date of Electronic Publication: 2025 May 24.
Publication Type: Journal Article
Journal Info: Publisher: Open Mind Journals Ltd Country of Publication: New Zealand NLM ID: 101150314 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1896 (Electronic) Linking ISSN: 11755652 NLM ISO Abbreviation: Appl Health Econ Health Policy Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1179-1896
DOI:10.1007/s40258-025-00977-6