PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents.

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Bibliographic Details
Title: PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents.
Authors: Aparnathi MK; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Cancer Biology and Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Ul Haq S; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Schulich School of Medicine & Dentistry, London, Ontario, Canada., St-Germain J; Protein Structure and Function, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Nixon KCJ; Cancer Biology and Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Walton J; Cancer Biology and Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Princess Margaret Cancer Research Tower, 101 College Street, Room 9-309, Toronto, ON, M5G 1L7, Canada., Song L; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Cancer Biology and Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Majeed S; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Princess Margaret Cancer Research Tower, 101 College Street, Room 9-309, Toronto, ON, M5G 1L7, Canada., Patel PS; Cancer Biology and Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Princess Margaret Cancer Research Tower, 101 College Street, Room 9-309, Toronto, ON, M5G 1L7, Canada., Subramaniam R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, ON, M5G 0A3, Canada., Philip V; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Cancer Biology and Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Marcellus R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, ON, M5G 0A3, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, ON, M5G 0A3, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada., Hakem R; Cancer Biology and Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Princess Margaret Cancer Research Tower, 101 College Street, Room 9-309, Toronto, ON, M5G 1L7, Canada., Arrowsmith CH; Protein Structure and Function, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Princess Margaret Cancer Research Tower, 101 College Street, Room 9-309, Toronto, ON, M5G 1L7, Canada; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Ailles L; Cancer Biology and Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Princess Margaret Cancer Research Tower, 101 College Street, Room 9-309, Toronto, ON, M5G 1L7, Canada., Raught B; Protein Structure and Function, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Lok BH; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Cancer Biology and Imaging, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 2374, Toronto, ON, M5S 1A8, Canada; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Princess Margaret Cancer Research Tower, 101 College Street, Room 9-309, Toronto, ON, M5G 1L7, Canada; Department of Radiation Oncology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: benjamin.lok@uhn.ca.
Source: Neoplasia (New York, N.Y.) [Neoplasia] 2025 Aug; Vol. 66, pp. 101176. Date of Electronic Publication: 2025 May 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5586
DOI:10.1016/j.neo.2025.101176