Impact of Polygenic Interactions With Anticholinergic Burden on Cognition and Brain Structure in Psychosis Spectrum Disorders.

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Title: Impact of Polygenic Interactions With Anticholinergic Burden on Cognition and Brain Structure in Psychosis Spectrum Disorders.
Authors: Zhang L; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Ivleva EI; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Parker DA; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Hill SK; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Lizano PL; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Keefe RSE; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Keedy SK; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., McDowell JE; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Pearlson GD; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Clementz BA; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Keshavan MS; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Gershon ES; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Tamminga CA; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Sweeney JA; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop)., Bishop JR; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop).
Source: The American journal of psychiatry [Am J Psychiatry] 2025 Aug 01; Vol. 182 (8), pp. 751-762. Date of Electronic Publication: 2025 May 28.
Publication Type: Journal Article
Journal Info: Publisher: American Psychiatric Association Country of Publication: United States NLM ID: 0370512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-7228 (Electronic) Linking ISSN: 0002953X NLM ISO Abbreviation: Am J Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1535-7228
DOI:10.1176/appi.ajp.20240709