DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.

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Title: DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.
Authors: Modafferi S; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Farina S; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy., Esposito F; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Brandi O; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Di Salvio M; Institute of Molecular Biology and Pathology, CNR, Rome, Italy., Della Valle I; PhD Program in Cellular and Molecular Biology, Department of Biology, University of Rome Tor Vergata, Rome, Italy., D'Uva S; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Scarian E; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia, Italy., Cicio G; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy., Riccardi A; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Pisati F; Cogentech Società Benefit srl, Milan, Italy., Garbelli A; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Santini T; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Pansarasa O; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia, Italy., Morlando M; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., D'Ambrosi N; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Cozzolino M; Institute of Translational Pharmacology, CNR, Rome, Italy., Cestra G; Institute of Molecular Biology and Pathology, CNR, Rome, Italy.; Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., d'Adda di Fagagna F; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy., Gioia U; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy. ubaldo.gioia@cnr.it.; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy. ubaldo.gioia@cnr.it., Francia S; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy. sofia.francia@cnr.it.
Source: Cell death and differentiation [Cell Death Differ] 2025 Dec; Vol. 32 (12), pp. 2309-2322. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5403
DOI:10.1038/s41418-025-01530-7