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DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.

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Title: DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.
Authors: Modafferi S; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Farina S; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy., Esposito F; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Brandi O; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Di Salvio M; Institute of Molecular Biology and Pathology, CNR, Rome, Italy., Della Valle I; PhD Program in Cellular and Molecular Biology, Department of Biology, University of Rome Tor Vergata, Rome, Italy., D'Uva S; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Scarian E; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia, Italy., Cicio G; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy., Riccardi A; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Pisati F; Cogentech Società Benefit srl, Milan, Italy., Garbelli A; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy., Santini T; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Pansarasa O; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia, Italy., Morlando M; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., D'Ambrosi N; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Cozzolino M; Institute of Translational Pharmacology, CNR, Rome, Italy., Cestra G; Institute of Molecular Biology and Pathology, CNR, Rome, Italy.; Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., d'Adda di Fagagna F; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy., Gioia U; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy. ubaldo.gioia@cnr.it.; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy. ubaldo.gioia@cnr.it., Francia S; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy. sofia.francia@cnr.it.
Source: Cell death and differentiation [Cell Death Differ] 2025 Dec; Vol. 32 (12), pp. 2309-2322. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Modafferi+S%22">Modafferi S</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Farina+S%22">Farina S</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Esposito+F%22">Esposito F</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Brandi+O%22">Brandi O</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Salvio+M%22">Di Salvio M</searchLink>; Institute of Molecular Biology and Pathology, CNR, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Della+Valle+I%22">Della Valle I</searchLink>; PhD Program in Cellular and Molecular Biology, Department of Biology, University of Rome Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22D'Uva+S%22">D'Uva S</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Scarian+E%22">Scarian E</searchLink>; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Cicio+G%22">Cicio G</searchLink>; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Riccardi+A%22">Riccardi A</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Pisati+F%22">Pisati F</searchLink>; Cogentech Società Benefit srl, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Garbelli+A%22">Garbelli A</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Santini+T%22">Santini T</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pansarasa+O%22">Pansarasa O</searchLink>; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Morlando+M%22">Morlando M</searchLink>; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22D'Ambrosi+N%22">D'Ambrosi N</searchLink>; Department of Biology, University of Rome Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cozzolino+M%22">Cozzolino M</searchLink>; Institute of Translational Pharmacology, CNR, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cestra+G%22">Cestra G</searchLink>; Institute of Molecular Biology and Pathology, CNR, Rome, Italy.; Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22d'Adda+di+Fagagna+F%22">d'Adda di Fagagna F</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy.; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gioia+U%22">Gioia U</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy. ubaldo.gioia@cnr.it.; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy. ubaldo.gioia@cnr.it.<br /><searchLink fieldCode="AU" term="%22Francia+S%22">Francia S</searchLink>; Institute of Molecular Genetics 'Luigi Luca Cavalli-Sforza', National Research Council (CNR), Pavia, Italy. sofia.francia@cnr.it.
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