BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways.

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Title: BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways.
Authors: Hirani R; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Nandakumar S; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zaman N; Departments of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Departments of Oncological Sciences Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Prabhakaraalva P; Departments of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Departments of Oncological Sciences Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., King SA; Departments of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Departments of Oncological Sciences Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kalidindi TM; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ghale R; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rajanala SH; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fidele DC; Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY, USA., De Stanchina E; Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mary Lee GS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Taplin ME; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Balk SP; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Sowalsky AG; Genitourinary Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD, USA., Morris MJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kishore Pillarsetty NV; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Stopsack KH; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Gopalan A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mucci LA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Kyprianou N; Departments of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Departments of Oncological Sciences Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tewari AK; Departments of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Danila D; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kantoff PW; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Convergent Therapeutics Inc., Boston, MA, USA., Chakraborty G; Departments of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Departments of Oncological Sciences Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: goutam.chakraborty@mountsinai.org.
Source: Cell reports [Cell Rep] 2025 Jun 24; Vol. 44 (6), pp. 115779. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2025.115779