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Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome.

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Title: Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome.
Authors: Fissolo N; Servei de Neurologia and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain.; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED) - ISCIII, Madrid, Spain., Schaedelin S; Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland., Villar LM; Departments of Neurology and Immunology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria., Lünemann JD; Department of Neurology and Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Correale J; Department of Neurology, Fleni, Buenos Aires, Argentina; Institute of Biological Chemistry and Biophysics, CONICET/University of Buenos Aires, Buenos Aires, Argentina., Rejdak K; Department of Neurology, Medical University of Lublin, Lublin, Poland., Schwab N; Department of Neurology and Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Vilaseca A; Servei de Neurologia and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain., Held F; Department of Neurology, School of Medicine and Health, Technical University of Munich, Klinikum rechts der Isar, München, Germany., García-Merino A; Neuroimmunology Unit, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain., Bittner S; Department of Neurology, Research Center for Immunotherapy (FZI) and Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (Rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Trojano M; Department of Translational Biomedicines and Neurosciences, University of Bari Aldo Moro, Bari, Italy., Furlan R; Neuroimmunology Unit, Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy., Tumani H; Department of Neurology, University Hospital Ulm, Ulm, Germany., Pérez-Miralles F; Neuroinmunology Unit, University and Polytechnic La Fe Hospital, Valencia, Spain., Rosenstein I; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden., Galimberti D; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy., Álvarez-Bravo G; Neuroimmunology and Multiple Sclerosis Unit, Department of Neurology, Dr. Josep Trueta University Hospital, Girona Biomedical Research Institute (IDIBGI), Girona, Spain., Thouvenot E; Department of Neurology, Nîmes University Hospital, Nîmes, France.; Institut de Génomique Fonctionnelle, Univ Montpellier, CNRS, INSERM, Montpellier, France., Llufriu S; Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Center of Neuroimmunology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques, Barcelona, Spain., Khoury SJ; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon., Hoepner R; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland., Martínez-Yélamos S; Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge. Neurology and Neurogenetics Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Department of Clinical Sciences, School of Medicine, Universitat de Barcelona (UB), L'Hospitalet de Llobregat, Spain., Hegen H; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Drulovic J; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia., Téllez-Lara N; Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Khalil M; Department of Neurology, Medical University of Graz, Graz, Austria., Oechtering J; Department of Neurology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland., Pérez-Sempere Á; Hospital General Universitario de Alicante, Alicante, Spain., Rodríguez-Antigüedad A; Neurology Department, Cruces-BioCruces Bizkaia University Hospital, Barakaldo-Bizkaia, Spain., Enrique-Martínez J; Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain., Strijbis E; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VU Medical Centre, Amsterdam, the Netherlands., Killestein J; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VU Medical Centre, Amsterdam, the Netherlands., Eichau S; Neurology Department, Virgen Macarena University Hospital, Sevilla, Spain., Colombo E; Multiple Sclerosis Centre, IRCCS Mondino Foundation, Pavia, Italy., Schaller-Nagengast J; Department of Neurology, University Hospital Ulm, Ulm, Germany., Midaglia L; Servei de Neurologia and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain., Sánchez-López AJ; Neuroimmunology Unit, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain., Monreal E; Department of Neurology, Hospital Universitario Ramón y Cajal, REEM, IRYCIS, Universidad de Alcalá, Madrid, Spain., Chan A; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland., Paul F; Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité Universitaetsmedizin Berlin, Berlin, Germany., Rovira À; Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Tintoré M; Servei de Neurologia and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain.; Universitat de Vic-Universitat Central de Catalunya (Uvic-UCC), Vic, Catalonia, Spain., Lycke J; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden., Zipp F; Department of Neurology, Research Center for Immunotherapy (FZI) and Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (Rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Hemmer B; Department of Neurology, School of Medicine and Health, Technical University of Munich, Klinikum rechts der Isar, München, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Kuhle J; Department of Neurology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland., Montalban X; Servei de Neurologia and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain.; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED) - ISCIII, Madrid, Spain.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Comabella M; Servei de Neurologia and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain.; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED) - ISCIII, Madrid, Spain.
Corporate Authors: RIS Study Group
Source: JAMA neurology [JAMA Neurol] 2025 Jul 01; Vol. 82 (7), pp. 722-733.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2168-6157
DOI:10.1001/jamaneurol.2025.1481