Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro.

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Title: Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro.
Authors: Shah VS; Simches 4, Northeast Corridor, Massachusetts General Hospital, Boston, MA, USA.; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waghray A; Simches 4, Northeast Corridor, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Immunology and Inflammation Research Therapeutic Area, Sanofi, Cambridge, MA, USA., Lin B; Simches 4, Northeast Corridor, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA., Bhagwat A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai (ISMMS), New York, USA., Monga I; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai (ISMMS), New York, USA., Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Giotti B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai (ISMMS), New York, USA., Kim S; Simches 4, Northeast Corridor, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Sun D; Simches 4, Northeast Corridor, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Xu K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai (ISMMS), New York, USA., Park E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai (ISMMS), New York, USA., Bairakdar M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai (ISMMS), New York, USA., Xu J; Simches 4, Northeast Corridor, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Waldman J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dionne D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen LT; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lou W; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cai P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai (ISMMS), New York, USA., Muus C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Sun J; Simches 4, Northeast Corridor, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Surve MV; Simches 4, Northeast Corridor, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yang LCC; Harvard College, Boston, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Delorey TM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Saladi SV; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cell and Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com., Rajagopal J; Simches 4, Northeast Corridor, Massachusetts General Hospital, Boston, MA, USA. jrajagopal@mgh.harvard.edu.; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA. jrajagopal@mgh.harvard.edu.; Harvard Stem Cell Institute, Cambridge, MA, USA. jrajagopal@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. jrajagopal@mgh.harvard.edu.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. jrajagopal@mgh.harvard.edu., Tsankov AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai (ISMMS), New York, USA. alexander.tsankov@mssm.edu.
Source: Nature communications [Nat Commun] 2025 Jun 04; Vol. 16 (1), pp. 5180. Date of Electronic Publication: 2025 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-60441-w