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ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration.

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Title: ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration.
Authors: Liu XW; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China., Xu HW; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China., Zhang SB; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China., Yi YY; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China., Chang SJ; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China., Wang SJ; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China. kingspine@163.com.
Source: Cell death discovery [Cell Death Discov] 2025 Jun 04; Vol. 11 (1), pp. 267. Date of Electronic Publication: 2025 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration.
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  Data: <searchLink fieldCode="AU" term="%22Liu+XW%22">Liu XW</searchLink>; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+HW%22">Xu HW</searchLink>; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+SB%22">Zhang SB</searchLink>; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yi+YY%22">Yi YY</searchLink>; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chang+SJ%22">Chang SJ</searchLink>; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+SJ%22">Wang SJ</searchLink>; Department of Spinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200092, Shanghai, China. kingspine@163.com.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2025 Jun 04; Vol. 11 (1), pp. 267. <i>Date of Electronic Publication: </i>2025 Jun 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
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      – TitleFull: ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration.
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              Text: 2025 Jun 04
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