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Probing condensate microenvironments with a micropeptide killswitch.

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Title: Probing condensate microenvironments with a micropeptide killswitch.
Authors: Zhang Y; Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany., Stöppelkamp I; Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany., Fernandez-Pernas P; Centre of Biological Sciences, University of Veterinary Medicine, Vienna, Austria., Allram M; Centre of Biological Sciences, University of Veterinary Medicine, Vienna, Austria., Charman M; Division of Protective Immunity, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Magalhaes AP; Max Planck Institute for Molecular Genetics, Berlin, Germany., Piedavent-Salomon M; Max Planck Institute for Molecular Genetics, Berlin, Germany., Sommer G; Max Planck Institute for Molecular Genetics, Berlin, Germany., Sung YC; Max Planck Institute for Molecular Genetics, Berlin, Germany., Meyer K; Max Planck Institute for Molecular Genetics, Berlin, Germany., Grams N; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Halko E; Division of Protective Immunity, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Dongre S; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Meierhofer D; Max Planck Institute for Molecular Genetics, Berlin, Germany., Malszycki M; Max Planck Institute for Molecular Genetics, Berlin, Germany., Ilik IA; Max Planck Institute for Molecular Genetics, Berlin, Germany., Aktas T; Max Planck Institute for Molecular Genetics, Berlin, Germany., Kraushar ML; Max Planck Institute for Molecular Genetics, Berlin, Germany., Vastenhouw N; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Weitzman MD; Division of Protective Immunity, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Grebien F; Centre of Biological Sciences, University of Veterinary Medicine, Vienna, Austria.; St Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Niskanen H; Max Planck Institute for Molecular Genetics, Berlin, Germany. niskanen@molgen.mpg.de., Hnisz D; Max Planck Institute for Molecular Genetics, Berlin, Germany. hnisz@molgen.mpg.de.
Source: Nature [Nature] 2025 Jul; Vol. 643 (8073), pp. 1107-1116. Date of Electronic Publication: 2025 Jun 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stöppelkamp+I%22">Stöppelkamp I</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Fernandez-Pernas+P%22">Fernandez-Pernas P</searchLink>; Centre of Biological Sciences, University of Veterinary Medicine, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Allram+M%22">Allram M</searchLink>; Centre of Biological Sciences, University of Veterinary Medicine, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Charman+M%22">Charman M</searchLink>; Division of Protective Immunity, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Magalhaes+AP%22">Magalhaes AP</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Piedavent-Salomon+M%22">Piedavent-Salomon M</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sommer+G%22">Sommer G</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sung+YC%22">Sung YC</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer+K%22">Meyer K</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Grams+N%22">Grams N</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Halko+E%22">Halko E</searchLink>; Division of Protective Immunity, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dongre+S%22">Dongre S</searchLink>; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meierhofer+D%22">Meierhofer D</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Malszycki+M%22">Malszycki M</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ilik+IA%22">Ilik IA</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Aktas+T%22">Aktas T</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kraushar+ML%22">Kraushar ML</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Vastenhouw+N%22">Vastenhouw N</searchLink>; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Weitzman+MD%22">Weitzman MD</searchLink>; Division of Protective Immunity, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Grebien+F%22">Grebien F</searchLink>; Centre of Biological Sciences, University of Veterinary Medicine, Vienna, Austria.; St Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Niskanen+H%22">Niskanen H</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany. niskanen@molgen.mpg.de.<br /><searchLink fieldCode="AU" term="%22Hnisz+D%22">Hnisz D</searchLink>; Max Planck Institute for Molecular Genetics, Berlin, Germany. hnisz@molgen.mpg.de.
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