GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing.
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| Title: | GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing. |
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| Authors: | Huang A; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China., Guo DZ; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China., Su ZX; Singlera Genomics (Shanghai) Ltd., Shanghai, 201203, China., Zhong YS; Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Liu L; Department of Pancreatic Surgery, Cancer Center, Department of General Surgery, Zhongshan Hospital, Fudan University, Cancer Center, Shanghai, 200032, China., Xiong ZG; Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430079, China., He DL; Department of Gastroenterology, Xuhui Central Hospital, Zhongshan Hospital, Fudan University, Shanghai, 200031, China.; Endoscopy Center, Xuhui Central Hospital, Zhongshan Hospital, Fudan University, Shanghai, 200031, China., Yan B; Department of Clinical Laboratory, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201700, China., Li QL; Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Feng Z; Department of Gastroenterology, Xuhui Central Hospital, Zhongshan Hospital, Fudan University, Shanghai, 200031, China.; Endoscopy Center, Xuhui Central Hospital, Zhongshan Hospital, Fudan University, Shanghai, 200031, China., Wang WQ; Department of Pancreatic Surgery, Cancer Center, Department of General Surgery, Zhongshan Hospital, Fudan University, Cancer Center, Shanghai, 200032, China., Lu PX; Department of General Surgery, Xuhui Central Hospital, Shanghai, 20031, China., He MJ; Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Qi ZP; Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Guo Q; Endoscopy Center, Xuhui Central Hospital, Zhongshan Hospital, Fudan University, Shanghai, 200031, China., Cheng JW; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China., Zhang SY; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China., Guo W; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Li Q; Xiangya Medical Laboratory, Central South University, Changsha, 410078, China., Lin GY; Department of Respiratory and Critical Illness Medicine, The First Hospital of Putian, Putian, 351100, China., Sun HC; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China., Qiu SJ; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China., He QY; Singlera Genomics (Shanghai) Ltd., Shanghai, 201203, China., Fan J; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China., Goel A; Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, Monrovia, CA, USA.; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Liu R; Singlera Genomics (Shanghai) Ltd., Shanghai, 201203, China. rliu@singleragenomics.com., Jin G; Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Navy Medical University (the Second Military Medical University), Shanghai, 200433, China. jingang@smmu.edu.cn., Yang XR; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China. yang.xinrong@zs-hospital.sh.cn., Zhou J; Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China. zhou.jian@zs-hospital.sh.cn. |
| Source: | Molecular cancer [Mol Cancer] 2025 Jun 05; Vol. 24 (1), pp. 163. Date of Electronic Publication: 2025 Jun 05. |
| Publication Type: | Journal Article; Multicenter Study; Observational Study |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1476-4598 |
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| DOI: | 10.1186/s12943-025-02367-x |
