Pharmacokinetics and Pharmacodynamics of Intranasal Diacetylmorphine in Heroin-Assisted Treatment for Severe Opioid Use Disorder.

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Title: Pharmacokinetics and Pharmacodynamics of Intranasal Diacetylmorphine in Heroin-Assisted Treatment for Severe Opioid Use Disorder.
Authors: Guessoum A; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland., Vogt SB; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Clinical Research, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Meyer M; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland., Westenberg JN; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland., Klemperer B; Faculty of Medicine, University of Basel, Basel, Switzerland., Dürsteler KM; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland., Liechti ME; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Clinical Research, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Thomann J; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Luethi D; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Duthaler U; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, Basel, Switzerland., Vogel M; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland. marc.vogel@upk.ch.
Source: CNS drugs [CNS Drugs] 2025 Aug; Vol. 39 (8), pp. 807-817. Date of Electronic Publication: 2025 Jun 07.
Publication Type: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1179-1934
DOI:10.1007/s40263-025-01189-1