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Pharmacokinetics and Pharmacodynamics of Intranasal Diacetylmorphine in Heroin-Assisted Treatment for Severe Opioid Use Disorder.

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Title: Pharmacokinetics and Pharmacodynamics of Intranasal Diacetylmorphine in Heroin-Assisted Treatment for Severe Opioid Use Disorder.
Authors: Guessoum A; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland., Vogt SB; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Clinical Research, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Meyer M; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland., Westenberg JN; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland., Klemperer B; Faculty of Medicine, University of Basel, Basel, Switzerland., Dürsteler KM; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland., Liechti ME; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Clinical Research, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Thomann J; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Luethi D; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Duthaler U; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, Basel, Switzerland., Vogel M; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland. marc.vogel@upk.ch.
Source: CNS drugs [CNS Drugs] 2025 Aug; Vol. 39 (8), pp. 807-817. Date of Electronic Publication: 2025 Jun 07.
Publication Type: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE
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  Data: Pharmacokinetics and Pharmacodynamics of Intranasal Diacetylmorphine in Heroin-Assisted Treatment for Severe Opioid Use Disorder.
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  Data: <searchLink fieldCode="AU" term="%22Guessoum+A%22">Guessoum A</searchLink>; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vogt+SB%22">Vogt SB</searchLink>; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Clinical Research, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meyer+M%22">Meyer M</searchLink>; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Westenberg+JN%22">Westenberg JN</searchLink>; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Klemperer+B%22">Klemperer B</searchLink>; Faculty of Medicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dürsteler+KM%22">Dürsteler KM</searchLink>; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Liechti+ME%22">Liechti ME</searchLink>; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Clinical Research, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thomann+J%22">Thomann J</searchLink>; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Luethi+D%22">Luethi D</searchLink>; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Duthaler+U%22">Duthaler U</searchLink>; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vogel+M%22">Vogel M</searchLink>; University Psychiatric Clinics Basel, University of Basel, Marc Vogel Wilhelm-Klein-Strasse 27, 4002, Basel, Switzerland. marc.vogel@upk.ch.
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