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The macrophage-intrinsic MDA5/IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses.

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Title: The macrophage-intrinsic MDA5/IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses.
Authors: Ramaswamy S; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Akiyama H; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Berrigan J; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Quiñones-Molina AA; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Olson AJ; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA., Chen Y; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA., Liang Y; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA., Henderson AJ; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA., Asundi A; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA., Sagar M; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA., Gummuluru S; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Jun 10; Vol. 135 (16). Date of Electronic Publication: 2025 Jun 10 (Print Publication: 2025).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The macrophage-intrinsic MDA5/IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses.
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  Data: <searchLink fieldCode="AU" term="%22Ramaswamy+S%22">Ramaswamy S</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Akiyama+H%22">Akiyama H</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Berrigan+J%22">Berrigan J</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Quiñones-Molina+AA%22">Quiñones-Molina AA</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Olson+AJ%22">Olson AJ</searchLink>; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Henderson+AJ%22">Henderson AJ</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Asundi+A%22">Asundi A</searchLink>; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sagar+M%22">Sagar M</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gummuluru+S%22">Gummuluru S</searchLink>; Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2025 Jun 10; Vol. 135 (16). <i>Date of Electronic Publication: </i>2025 Jun 10 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE
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        Value: 10.1172/JCI187663
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              Text: 2025 Jun 10
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