Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody-STING agonist conjugates.

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Title: Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody-STING agonist conjugates.
Authors: Kimmel BR; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA., Arora K; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Chada NC; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Bharti V; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Kwiatkowski AJ; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Finkelstein JE; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Hanna A; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Arner EN; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sheehy TL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Pastora LE; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Yang J; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Pagendarm HM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Stone PT; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Hargrove-Wiley E; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Taylor BC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hubert LA; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Fingleton BM; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Gibson-Corley KN; Division of Comparative Medicine, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., May JC; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., McLean JA; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Rathmell JC; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Richmond A; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Rathmell WK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Balko JM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Wilson JT; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Oct; Vol. 9 (10), pp. 1719-1739. Date of Electronic Publication: 2025 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2157-846X
DOI:10.1038/s41551-025-01400-0