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Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody-STING agonist conjugates.

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Title: Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody-STING agonist conjugates.
Authors: Kimmel BR; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA., Arora K; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Chada NC; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Bharti V; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Kwiatkowski AJ; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Finkelstein JE; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Hanna A; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Arner EN; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sheehy TL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Pastora LE; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Yang J; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Pagendarm HM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Stone PT; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Hargrove-Wiley E; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Taylor BC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hubert LA; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Fingleton BM; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Gibson-Corley KN; Division of Comparative Medicine, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., May JC; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., McLean JA; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Rathmell JC; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Richmond A; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Rathmell WK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Balko JM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Wilson JT; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Oct; Vol. 9 (10), pp. 1719-1739. Date of Electronic Publication: 2025 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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  Data: Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody-STING agonist conjugates.
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  Data: <searchLink fieldCode="AU" term="%22Kimmel+BR%22">Kimmel BR</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Arora+K%22">Arora K</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chada+NC%22">Chada NC</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bharti+V%22">Bharti V</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kwiatkowski+AJ%22">Kwiatkowski AJ</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Finkelstein+JE%22">Finkelstein JE</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hanna+A%22">Hanna A</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Arner+EN%22">Arner EN</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sheehy+TL%22">Sheehy TL</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Pastora+LE%22">Pastora LE</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Pagendarm+HM%22">Pagendarm HM</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Stone+PT%22">Stone PT</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hargrove-Wiley+E%22">Hargrove-Wiley E</searchLink>; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+BC%22">Taylor BC</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hubert+LA%22">Hubert LA</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Fingleton+BM%22">Fingleton BM</searchLink>; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Gibson-Corley+KN%22">Gibson-Corley KN</searchLink>; Division of Comparative Medicine, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22May+JC%22">May JC</searchLink>; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22McLean+JA%22">McLean JA</searchLink>; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rathmell+JC%22">Rathmell JC</searchLink>; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Richmond+A%22">Richmond A</searchLink>; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rathmell+WK%22">Rathmell WK</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Balko+JM%22">Balko JM</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+JT%22">Wilson JT</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA. john.t.wilson@vanderbilt.edu.
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  Data: <searchLink fieldCode="JN" term="%22101696896%22">Nature biomedical engineering</searchLink> [Nat Biomed Eng] 2025 Oct; Vol. 9 (10), pp. 1719-1739. <i>Date of Electronic Publication: </i>2025 Jun 11.
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