Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease.

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Title: Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease.
Authors: Shi L; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, 10027, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Uzuni A; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA., Wang XK; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA., Pressler M; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Harle DW; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA.; Columbia Institute of Human Nutrition, Columbia University, New York, NY, 10032, USA., Chakrabarti S; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA., Macedo R; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA., Belay K; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Gordillo CA; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA., Raps E; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Zhang JYA; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, 10027, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Nazaret A; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, 10027, USA.; Department of Computer Science, Columbia University, New York, NY, 10027, USA., Fan JL; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, 10027, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Jin Y; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, 10027, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Shen X; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Fuller JS; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Azad T; Department of Computer Science, Columbia University, New York, NY, 10027, USA., Huang J; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Chainani P; Department Statistics and Data Science, Yale University, CT, 06520, USA., Abrams JA; Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA., Del Portillo A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA., Mapara MY; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA., Alhamar M; Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, 48202, USA., Sykes M; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., McFaline-Figueroa JL; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, 10027, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Azizi E; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, 10027, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA.; Department of Computer Science, Columbia University, New York, NY, 10027, USA.; Data Science Institute, Columbia University, New York, NY, 10027, USA., Reshef R; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 28. Date of Electronic Publication: 2025 May 28.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.05.24.655962