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Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis.

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Title: Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis.
Authors: Ding YL; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Qiao LJ; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Fang H; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Fan LL; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Wu D; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Xu JP; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Lv QH; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Deng MZ; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Qiu YH; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Zhou ZY; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Huang Y; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China., Zheng JY; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China. zhengjiayi@gzucm.edu.cn.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. zhengjiayi@gzucm.edu.cn.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China. zhengjiayi@gzucm.edu.cn.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China. zhengjiayi@gzucm.edu.cn., Zhang SJ; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China. shijiezhang@gzucm.edu.cn.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. shijiezhang@gzucm.edu.cn.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China. shijiezhang@gzucm.edu.cn.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China. shijiezhang@gzucm.edu.cn., Cai YF; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China. caiyefeng@126.com.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. caiyefeng@126.com.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China. caiyefeng@126.com.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China. caiyefeng@126.com.
Source: Neurochemical research [Neurochem Res] 2025 Jun 13; Vol. 50 (3), pp. 201. Date of Electronic Publication: 2025 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Ding+YL%22">Ding YL</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Qiao+LJ%22">Qiao LJ</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Fang+H%22">Fang H</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Fan+LL%22">Fan LL</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Wu+D%22">Wu D</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Xu+JP%22">Xu JP</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Lv+QH%22">Lv QH</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Deng+MZ%22">Deng MZ</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Qiu+YH%22">Qiu YH</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Zhou+ZY%22">Zhou ZY</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China.<br /><searchLink fieldCode="AU" term="%22Zheng+JY%22">Zheng JY</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China. zhengjiayi@gzucm.edu.cn.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. zhengjiayi@gzucm.edu.cn.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China. zhengjiayi@gzucm.edu.cn.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China. zhengjiayi@gzucm.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+SJ%22">Zhang SJ</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China. shijiezhang@gzucm.edu.cn.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. shijiezhang@gzucm.edu.cn.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China. shijiezhang@gzucm.edu.cn.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China. shijiezhang@gzucm.edu.cn.<br /><searchLink fieldCode="AU" term="%22Cai+YF%22">Cai YF</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510405, China. caiyefeng@126.com.; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. caiyefeng@126.com.; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510405, China. caiyefeng@126.com.; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, 510000, China. caiyefeng@126.com.
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  Data: <searchLink fieldCode="JN" term="%227613461%22">Neurochemical research</searchLink> [Neurochem Res] 2025 Jun 13; Vol. 50 (3), pp. 201. <i>Date of Electronic Publication: </i>2025 Jun 13.
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        Value: 10.1007/s11064-025-04452-5
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      – TitleFull: Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis.
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              Text: 2025 Jun 13
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