Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis.
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| Title: | Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis. |
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| Authors: | Daum AK; Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; German Center for Lung Research (DZL), TLRC Heidelberg, Heidelberg, Germany.; Medical Faculty, Heidelberg University, Heidelberg, Germany., Schlicker L; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schneider MA; German Center for Lung Research (DZL), TLRC Heidelberg, Heidelberg, Germany.; Translational Research Unit, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany., Muley T; German Center for Lung Research (DZL), TLRC Heidelberg, Heidelberg, Germany.; Translational Research Unit, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany., Klingmüller U; German Center for Lung Research (DZL), TLRC Heidelberg, Heidelberg, Germany.; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Thomas M; German Center for Lung Research (DZL), TLRC Heidelberg, Heidelberg, Germany.; Department of Oncology, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany., Christopoulos P; German Center for Lung Research (DZL), TLRC Heidelberg, Heidelberg, Germany.; Department of Oncology, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany., Sültmann H; Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. h.sueltmann@dkfz.de.; German Center for Lung Research (DZL), TLRC Heidelberg, Heidelberg, Germany. h.sueltmann@dkfz.de. |
| Source: | Cancer & metabolism [Cancer Metab] 2025 Jun 16; Vol. 13 (1), pp. 28. Date of Electronic Publication: 2025 Jun 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101607582 Publication Model: Electronic Cited Medium: Print ISSN: 2049-3002 (Print) Linking ISSN: 20493002 NLM ISO Abbreviation: Cancer Metab Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2049-3002 |
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| DOI: | 10.1186/s40170-025-00400-7 |
