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Gu Han Yang Sheng Jing improves major depressive disorder via attenuating neuroinflammation by inhibiting AKT1/p65 signaling pathway based on network pharmacology analysis and experimental validation.

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Title: Gu Han Yang Sheng Jing improves major depressive disorder via attenuating neuroinflammation by inhibiting AKT1/p65 signaling pathway based on network pharmacology analysis and experimental validation.
Authors: Li X; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China., Yang SQ; Department of Anesthesiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China., Zhang HJ; Department of Cardiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China., Zhong Y; TUS-PHARMA Group Co., Ltd, PR China., Wen G; TUS-PHARMA Group Co., Ltd, PR China. Electronic address: 617608782@qq.com., Kang X; Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China. Electronic address: kangxuan-usc@qq.com., Xiao ZJ; Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China. Electronic address: zijian6340@21cn.com.
Source: Journal of ethnopharmacology [J Ethnopharmacol] 2025 Aug 29; Vol. 352, pp. 120146. Date of Electronic Publication: 2025 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-7573
DOI:10.1016/j.jep.2025.120146