Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.
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| Title: | Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids. |
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| Authors: | Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, 20892, USA. amy.bentley@nih.gov., Brown MR; Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Musani SK; MerexAgRight Farm, Ltd., Kitale, Kenya., Schwander KL; Division of Statistical Genomics, Washington University, St. Louis, MO, USA., Winkler TW; Department of Epidemiology, University of Regensburg, Regensburg, 93051, Germany., Sims M; Department of Social Medicine, Population and Public Health, University of California, Riverside School of Medicine, Riverside, CA, 92521, USA., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DK-2200, Denmark.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Aschard H; Institut Pasteur, Université Paris Cité, Department of Computational Biology, F-75015, Paris, France.; Department of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA., Bartz TM; Department of Biostatistics, University of Washington, Seattle, WA, 98101, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, 117549, Singapore., Chitrala KN; Department of Engineering Technology, University of Houston, Sugar Land, TX, 77479, USA., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Guo X; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Hartwig FP; Department of Epidemiology, Federal University of Pelotas, Pelotas, RS, 96020-220, Brazil., Horimoto ARVR; Department of Biostatistics, University of Washington, Seattle, WA, 98101, USA.; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, 05403-900, Brazil., Lim E; Department of Biostatistics, Boston University, Boston, MA, 02118, USA., Liu Y; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, 27701-2047, USA., Manning AK; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands., Richard MA; McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, USA., Smith AV; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Sung YJ; Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA., Vojinovic D; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.; IQVIA, 1101 CT, Amsterdam, the Netherlands., Wang R; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Wang Y; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Feitosa MF; Division of Statistical Genomics, Washington University, St. Louis, MO, USA., Harris SE; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Pistis G; Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Vaud, 1008, Switzerland., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands., Ware E; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Weiss S; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17489, Germany.; German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, 17475, Germany., Wen W; Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, 37203, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Arnett DK; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29169, USA., Ballantyne C; Section of Cardiovascular Research, Baylor College of Medicine, Houston, TX, 77030, USA.; Houston Methodist Debakey Heart and Vascular Center, Houston, TX, 77030, USA., Boerwinkle E; Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA., Chen YI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Daviglus ML; Institute for Minority Health Research, University of Illinois Chicago, Chicago, IL, 60612, USA., de Las Fuentes L; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics (I2BD), Washington University School of Medicine, St. Louis, MO, 63110, USA.; Division of Cardiology, Washington University, St. Louis, MO, 63110, USA., de Vries PS; Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Delaney JAC; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; College of Pharmacy, University of Manitoba, Winnipeg, MB, R3E 0T5, Canada., Fretts AM; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Ekunwe L; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39213, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Gallo LC; Department of Psychology, San Diego State University, San Diego, CA, USA., Heikkinen S; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, 70100, Finland., Homuth G; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17489, Germany., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Isasi CR; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Jonas JB; Institute of Molecular and Clinical Ophthalmology Basel IOB, Basel, Switzerland.; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Keltikangas-Järvinen L; Department of Psychology and Logopedics, University of Helsinki, Helsinki, 00014, Finland., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Kraja AT; University of Mississippi Medical Center, Jackson, MS, 39213, USA., Krieger JE; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, 05403-900, Brazil., Launer L; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 138672, Singapore., Lohman K; Department of Medicine, Duke Molecular Physiology Institute Duke University School of Medicine, Durham, NC, 27701-2047, USA., Luik AI; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Manichaikul AW; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, CH- 1011, Lausanne, Switzerland., Milaneschi Y; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081 HJ, the Netherlands., Mwasongwe SE; Veritas Management Group, Inc., Alpharetta, GA, 30072, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Rice K; Department of Biostatistics, University of Washington, Seattle, WA, 98101, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA., Schreiner PJ; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA., Schwettmann L; Department of Health Services Research, School of Medicine and Health Services, Carl von Ossietzky Universität Oldenburg, Oldenburg, 26111, Germany.; Institute for Health Economics and Health Care Management, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany., Shikany JM; Division of Preventive Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205, USA., Shu XO; Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, 37203, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington, 98195, USA., Tai ES; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore, 119228, Singapore., Taylor KD; Department of Pediatrics, LA Biomed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Tinker L; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA., Tsai MY; Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA., Uitterlinden AG; Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands., Waldenberger M; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany., Wallace RB; Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA., Wee HL; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, 117549, Singapore., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Wei WB; Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Willems van Dijk K; Department of Human Genetics, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands., Wilson G; School of Public Health, Jackson State University, Jackson, MS, 39213, USA., Yao J; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Young KL; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Zhang X; Department of Biostatistics, Boston University, Boston, MA, 02118, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Deary IJ; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK., Gieger C; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Partner München-Neuherberg, Neuherberg, Germany., Grabe HJ; German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, 17475, Germany.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, 17489, Germany., Lakka TA; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, 70100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, the Netherlands., Preisig M; Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Vaud, 1008, Switzerland., Wang YX; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Zheng W; Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, 37203, USA., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Province M; Division of Statistical Genomics, Washington University, St. Louis, MO, USA., Gauderman J; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, 90032, USA., Gudnason V; Icelandic Heart Association, Icelandic Heart Association, Kópavogur, 201, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, the Netherlands., Horta BL; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, 96020-220, Brazil., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Kooperberg C; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA., Liu CT; Department of Biostatistics, Boston University, Boston, MA, 02118, USA., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands., Penninx BW; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081 HJ, the Netherlands., Pereira AC; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, 05403-900, Brazil., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, USA., Rotter JI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, 117549, Singapore., North KE; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Rao DC; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics (I2BD), Washington University School of Medicine, St. Louis, MO, 63110, USA., Bierut L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA., Miller CL; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA., Morrison AC; Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, 20892, USA., Fornage M; McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Fox ER; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39213, USA. |
| Corporate Authors: | Lifelines Cohort Study |
| Source: | Translational psychiatry [Transl Psychiatry] 2025 Jun 20; Vol. 15 (1), pp. 207. Date of Electronic Publication: 2025 Jun 20. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2158-3188 |
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| DOI: | 10.1038/s41398-025-03418-z |
