Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers.

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Title: Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers.
Authors: Phung CD; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tran TTT; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Vingroup Science and Technology Scholarship Program, Vin University, Hanoi, Vietnam., Yeo BZJ; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Prajogo RC; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Saudjana E; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Yeo EYM; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Gao C; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Nguyen PHD; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Jayasinghe MK; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Dang XTT; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Lixuan CP; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore., Nguyen TM; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore., Peng B; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Le AH; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Nguyen TTT; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chan GME; Synthetic Biology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Loh YH; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore.; Integrative Sciences and Engineering Programme (ISEP), NUS Graduate School, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore., Goh BC; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Tam WL; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Genome Institute of Singapore, A*STAR, Singapore., Bonney GK; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore., Le MTN; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore.; Institute of Molecular and Cell Biology, A*STAR, Singapore.; Nanomedicine Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Source: Theranostics [Theranostics] 2025 Jun 09; Vol. 15 (14), pp. 6818-6838. Date of Electronic Publication: 2025 Jun 09 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1838-7640
DOI:10.7150/thno.105519