Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers.
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| Title: | Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers. |
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| Authors: | Phung CD; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tran TTT; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Vingroup Science and Technology Scholarship Program, Vin University, Hanoi, Vietnam., Yeo BZJ; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Prajogo RC; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Saudjana E; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Yeo EYM; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Gao C; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Nguyen PHD; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Jayasinghe MK; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Dang XTT; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Lixuan CP; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore., Nguyen TM; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore., Peng B; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Le AH; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Nguyen TTT; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chan GME; Synthetic Biology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Loh YH; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore.; Integrative Sciences and Engineering Programme (ISEP), NUS Graduate School, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore., Goh BC; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Tam WL; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Genome Institute of Singapore, A*STAR, Singapore., Bonney GK; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore., Le MTN; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore.; Institute of Molecular and Cell Biology, A*STAR, Singapore.; Nanomedicine Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. |
| Source: | Theranostics [Theranostics] 2025 Jun 09; Vol. 15 (14), pp. 6818-6838. Date of Electronic Publication: 2025 Jun 09 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40585984 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Phung+CD%22">Phung CD</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tran+TTT%22">Tran TTT</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Vingroup Science and Technology Scholarship Program, Vin University, Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Yeo+BZJ%22">Yeo BZJ</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Prajogo+RC%22">Prajogo RC</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Saudjana+E%22">Saudjana E</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yeo+EYM%22">Yeo EYM</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Gao+C%22">Gao C</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Nguyen+PHD%22">Nguyen PHD</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Jayasinghe+MK%22">Jayasinghe MK</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Dang+XTT%22">Dang XTT</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lixuan+CP%22">Lixuan CP</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore.<br /><searchLink fieldCode="AU" term="%22Nguyen+TM%22">Nguyen TM</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore.<br /><searchLink fieldCode="AU" term="%22Peng+B%22">Peng B</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Le+AH%22">Le AH</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Nguyen+TTT%22">Nguyen TTT</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+GME%22">Chan GME</searchLink>; Synthetic Biology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Loh+YH%22">Loh YH</searchLink>; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore.; Integrative Sciences and Engineering Programme (ISEP), NUS Graduate School, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+BC%22">Goh BC</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tam+WL%22">Tam WL</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Genome Institute of Singapore, A*STAR, Singapore.<br /><searchLink fieldCode="AU" term="%22Bonney+GK%22">Bonney GK</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Luo+D%22">Luo D</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Structural Biology, Nanyang Technological University, Singapore.<br /><searchLink fieldCode="AU" term="%22Le+MTN%22">Le MTN</searchLink>; Department of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore.; Institute of Molecular and Cell Biology, A*STAR, Singapore.; Nanomedicine Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101552395%22">Theranostics</searchLink> [Theranostics] 2025 Jun 09; Vol. 15 (14), pp. 6818-6838. <i>Date of Electronic Publication: </i>2025 Jun 09 (<i>Print Publication: </i>2025). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International+Publisher%22">Ivyspring International Publisher </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101552395 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1838-7640 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218387640%22">18387640 </searchLink><i>NLM ISO Abbreviation: </i>Theranostics <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40585984 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7150/thno.105519 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 6818 Titles: – TitleFull: Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Phung CD – PersonEntity: Name: NameFull: Tran TTT – PersonEntity: Name: NameFull: Yeo BZJ – PersonEntity: Name: NameFull: Prajogo RC – PersonEntity: Name: NameFull: Saudjana E – PersonEntity: Name: NameFull: Yeo EYM – PersonEntity: Name: NameFull: Gao C – PersonEntity: Name: NameFull: Nguyen PHD – PersonEntity: Name: NameFull: Jayasinghe MK – PersonEntity: Name: NameFull: Dang XTT – PersonEntity: Name: NameFull: Lixuan CP – PersonEntity: Name: NameFull: Nguyen TM – PersonEntity: Name: NameFull: Peng B – PersonEntity: Name: NameFull: Le AH – PersonEntity: Name: NameFull: Nguyen TTT – PersonEntity: Name: NameFull: Chan GME – PersonEntity: Name: NameFull: Loh YH – PersonEntity: Name: NameFull: Goh BC – PersonEntity: Name: NameFull: Tam WL – PersonEntity: Name: NameFull: Bonney GK – PersonEntity: Name: NameFull: Luo D – PersonEntity: Name: NameFull: Le MTN IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 06 Text: 2025 Jun 09 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1838-7640 Numbering: – Type: volume Value: 15 – Type: issue Value: 14 Titles: – TitleFull: Theranostics Type: main |
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