In vitro morphological profiling of T cells predicts clinical response to natalizumab therapy in patients with multiple sclerosis.
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| Title: | In vitro morphological profiling of T cells predicts clinical response to natalizumab therapy in patients with multiple sclerosis. |
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| Authors: | Chaves B; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.; Structural and Functional Biology of Biopharmaceuticals, Fiocruz-Ceará, Oswaldo Cruz Foundation (Fiocruz), Eusébio, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Santos E Silva JC; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Nakaya H; Hospital Israelita Albert Einstein, São Paulo, Brazil., Socquet-Juglard N; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Bucciarelli F; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.; Department of Neurosciences, Toulouse University Hospitals, Toulouse, France., Prunier G; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Almeida MV; Structural and Functional Biology of Biopharmaceuticals, Fiocruz-Ceará, Oswaldo Cruz Foundation (Fiocruz), Eusébio, Brazil., Lacouture C; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Kari S; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Astier AL; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Medeiros MA; Laboratory of Recombinant Technology, Bio-Manguinhos, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Silva JHM; Structural and Functional Biology of Biopharmaceuticals, Fiocruz-Ceará, Oswaldo Cruz Foundation (Fiocruz), Eusébio, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Liblau R; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.; Department of Immunology, Toulouse University Hospitals, Toulouse, France., Cotta-de-Almeida V; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. vinicius.almeida@fiocruz.br.; Laboratory on Thymus Research (LPT), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. vinicius.almeida@fiocruz.br.; Rio de Janeiro Research Network on Neuroinflammation (RENEURIN), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. vinicius.almeida@fiocruz.br., Dupré L; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France. loic.dupre@inserm.fr.; Department of Dermatology, Medical University of Vienna, Vienna, Austria. loic.dupre@inserm.fr. |
| Source: | Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5533. Date of Electronic Publication: 2025 Jul 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-60224-3 |
