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In vitro morphological profiling of T cells predicts clinical response to natalizumab therapy in patients with multiple sclerosis.

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Title: In vitro morphological profiling of T cells predicts clinical response to natalizumab therapy in patients with multiple sclerosis.
Authors: Chaves B; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.; Structural and Functional Biology of Biopharmaceuticals, Fiocruz-Ceará, Oswaldo Cruz Foundation (Fiocruz), Eusébio, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Santos E Silva JC; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Nakaya H; Hospital Israelita Albert Einstein, São Paulo, Brazil., Socquet-Juglard N; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Bucciarelli F; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.; Department of Neurosciences, Toulouse University Hospitals, Toulouse, France., Prunier G; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Almeida MV; Structural and Functional Biology of Biopharmaceuticals, Fiocruz-Ceará, Oswaldo Cruz Foundation (Fiocruz), Eusébio, Brazil., Lacouture C; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Kari S; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Astier AL; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France., Medeiros MA; Laboratory of Recombinant Technology, Bio-Manguinhos, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Silva JHM; Structural and Functional Biology of Biopharmaceuticals, Fiocruz-Ceará, Oswaldo Cruz Foundation (Fiocruz), Eusébio, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil., Liblau R; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.; Department of Immunology, Toulouse University Hospitals, Toulouse, France., Cotta-de-Almeida V; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. vinicius.almeida@fiocruz.br.; Laboratory on Thymus Research (LPT), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. vinicius.almeida@fiocruz.br.; Rio de Janeiro Research Network on Neuroinflammation (RENEURIN), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. vinicius.almeida@fiocruz.br., Dupré L; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France. loic.dupre@inserm.fr.; Department of Dermatology, Medical University of Vienna, Vienna, Austria. loic.dupre@inserm.fr.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5533. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: In vitro morphological profiling of T cells predicts clinical response to natalizumab therapy in patients with multiple sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Chaves+B%22">Chaves B</searchLink>; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.; Structural and Functional Biology of Biopharmaceuticals, Fiocruz-Ceará, Oswaldo Cruz Foundation (Fiocruz), Eusébio, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+E+Silva+JC%22">Santos E Silva JC</searchLink>; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Nakaya+H%22">Nakaya H</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Socquet-Juglard+N%22">Socquet-Juglard N</searchLink>; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Bucciarelli+F%22">Bucciarelli F</searchLink>; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.; Department of Neurosciences, Toulouse University Hospitals, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Prunier+G%22">Prunier G</searchLink>; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Almeida+MV%22">Almeida MV</searchLink>; Structural and Functional Biology of Biopharmaceuticals, Fiocruz-Ceará, Oswaldo Cruz Foundation (Fiocruz), Eusébio, Brazil.<br /><searchLink fieldCode="AU" term="%22Lacouture+C%22">Lacouture C</searchLink>; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Kari+S%22">Kari S</searchLink>; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Astier+AL%22">Astier AL</searchLink>; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Medeiros+MA%22">Medeiros MA</searchLink>; Laboratory of Recombinant Technology, Bio-Manguinhos, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+JHM%22">Silva JHM</searchLink>; Structural and Functional Biology of Biopharmaceuticals, Fiocruz-Ceará, Oswaldo Cruz Foundation (Fiocruz), Eusébio, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Liblau+R%22">Liblau R</searchLink>; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France.; Department of Immunology, Toulouse University Hospitals, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Cotta-de-Almeida+V%22">Cotta-de-Almeida V</searchLink>; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. vinicius.almeida@fiocruz.br.; Laboratory on Thymus Research (LPT), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. vinicius.almeida@fiocruz.br.; Rio de Janeiro Research Network on Neuroinflammation (RENEURIN), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. vinicius.almeida@fiocruz.br.<br /><searchLink fieldCode="AU" term="%22Dupré+L%22">Dupré L</searchLink>; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM U1291, CNRS UMR5051, Toulouse University, Toulouse, France. loic.dupre@inserm.fr.; Department of Dermatology, Medical University of Vienna, Vienna, Austria. loic.dupre@inserm.fr.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5533. <i>Date of Electronic Publication: </i>2025 Jul 01.
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