Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma.
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| Title: | Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma. |
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| Authors: | Sun NY; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Kumar S; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Kim YS; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Varghese D; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Mendoza A; Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Nguyen R; Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Okada R; Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Reilly K; Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Widemann B; Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Pommier Y; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Elloumi F; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Dhall A; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Taniyama D; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Patel M; Laboratory of Pathology, Center for Cancer Research, NCI, Bethesda, MD, USA., Aber E; Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Contreras CF; Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Kaplan RN; Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Kiseljak-Vassiliades K; Department of Medicine-Endocrinology/Metabolism/Diabetes, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.; Research Service Rocky Mountain, Regional Veterans Affairs Medical Center, Aurora, CO, USA., Wierman ME; Department of Medicine-Endocrinology/Metabolism/Diabetes, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA., Martinez D; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pogoriler J; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hamilton AK; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, and Children's Hospital of Philadelphia, Philadelphia, PA, USA., Diskin SJ; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, and Children's Hospital of Philadelphia, Philadelphia, PA, USA., Maris JM; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, and Children's Hospital of Philadelphia, Philadelphia, PA, USA., Robey RW; Laboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, MD, USA., Gottesman MM; Laboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, MD, USA., Del Rivero J; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA., Roper N; Developmental Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD, USA. nitin.roper@nih.gov. |
| Source: | Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5511. Date of Electronic Publication: 2025 Jul 01. |
| Publication Type: | Clinical Trial, Phase I; Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-60649-w |
