The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement.

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Title: The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement.
Authors: Perryman L; Syntara, Frenchs Forest, NSW, Australia., Findlay A; Syntara, Frenchs Forest, NSW, Australia., Baskar J; Syntara, Frenchs Forest, NSW, Australia., Charlton B; Syntara, Frenchs Forest, NSW, Australia., Foot J; Syntara, Frenchs Forest, NSW, Australia., Hamilton R; Syntara, Frenchs Forest, NSW, Australia., Hamprecht D; Syntara, Frenchs Forest, NSW, Australia., Joshi A; Syntara, Frenchs Forest, NSW, Australia., Stolp J; Syntara, Frenchs Forest, NSW, Australia., Turner C; Syntara, Frenchs Forest, NSW, Australia., Zahoor A; Syntara, Frenchs Forest, NSW, Australia., Zhou W; Syntara, Frenchs Forest, NSW, Australia., López B; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA , Pamplona, Spain.; CIBERCV, Carlos II Institute of Health, Madrid, Spain., Ravassa S; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA , Pamplona, Spain.; CIBERCV, Carlos II Institute of Health, Madrid, Spain., González A; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA , Pamplona, Spain.; CIBERCV, Carlos II Institute of Health, Madrid, Spain.; Department of Cardiology and Cardiac Surgery, Clínica Universidad de Navarra, Pamplona, Spain., Jarolimek W; Syntara, Frenchs Forest, NSW, Australia. Wolfgang.Jarolimek@Syntaratx.com.au.
Source: Scientific reports [Sci Rep] 2025 Jul 02; Vol. 15 (1), pp. 22653. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-025-06312-2