Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody.
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| Title: | Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody. |
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| Authors: | Li JX; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China.; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China., Tan SY; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Li LQ; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China., Zheng YH; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China., Zhao L; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China., Zhu HR; Shanghai University of Traditional Chinese Medicine, Shanghai, China., He HL; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Zhang YY; Henan Key Laboratory of Traditional Chinese Medicine Prescription and Syndrome Signaling, Henan University of Chinese Medicine, Zhengzhou, China., Li RZ; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China., Bao TY; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China., Zhang YZ; Chinese Medicine and Translational Medicine R&D center, Zhuhai UM Science & Technology Research Institute, Zhuhai, China., Yang XM; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China., Zhang H; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China., Chen HH; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China., Wu BW; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China., Lin X; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China., Lin XS; Guangzhou University of Chinese Medicine, Guangzhou, China.; BaoAn Central Hospital of Shenzhen, Shenzhen, China., Lin YC; Faculty of Medicine, Macau University of Science and Technology, Macau, China., Sui XB; School of Pharmacy, Hangzhou Normal University, Hangzhou, China., Xie Y; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China., Zhou XM; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Yan PY; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Macau, China. |
| Source: | Frontiers in pharmacology [Front Pharmacol] 2025 Jun 17; Vol. 16, pp. 1594213. Date of Electronic Publication: 2025 Jun 17 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1663-9812 |
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| DOI: | 10.3389/fphar.2025.1594213 |
