Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity.
Saved in:
| Title: | Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity. |
|---|---|
| Authors: | Bolton C; Infection, Immunity, and Inflammation Research and Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Mahony CB; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK., Clay E; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK., Nisa PR; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK., Lomholt S; Department of Biomedicine, Aarhus University, Aarhus, Denmark, DK-8000.; Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus DK-8200, Denmark., Hackland A; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.; Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Birmingham, Birmingham B15 2TT, UK., Chin PS; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK., Smith CG; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK., Alexiou V; Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, UCL, London WC1E 6JF, UK.; Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCL Hospitals and Great Ormond Street Hospital, London WC1E 6JF, UK., Nguyen HD; Infection, Immunity, and Inflammation Research and Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.; NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK., Thyagarajan M; Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham B15 2TG, UK., Sheikh Z; Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham B15 2TG, UK., Davis P; Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham B15 2TG, UK., Chippington S; NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK.; Department of Interventional Radiology, Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK., Compeyrot-Lacassagne S; NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK.; Department of Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK., Davda S; NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK.; Department of Interventional Radiology, Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK., Foley C; NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK.; Department of Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK., Turtsevich I; NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK.; Department of Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK., Ingledow B; Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, UCL, London WC1E 6JF, UK.; Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCL Hospitals and Great Ormond Street Hospital, London WC1E 6JF, UK., Kupiec K; NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK.; Department of Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK., Kelly J; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK., Hanlon MM; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., DiCarlo E; Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA., Jones LJ; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.; Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Birmingham, Birmingham B15 2TT, UK., Smith SL; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WU, UK., Eyre S; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK.; National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WU, UK., Neag G; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK., Kemble S; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK., Madhu R; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Palshikar MG; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Korsunsky I; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Gao C; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Tran M; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Dendrou C; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK., Buckley CD; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.; National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre, Oxford OX3 9DU, UK.; Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Oxford, Oxford OX3 7FY, UK., Coles MC; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.; Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Oxford, Oxford OX3 7FY, UK., Raza K; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.; Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Birmingham, Birmingham B15 2TT, UK.; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham B15 2TH, UK., Gravallese E; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Filer A; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.; Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Birmingham, Birmingham B15 2TT, UK.; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham B15 2TH, UK., Wei K; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Al-Abadi E; Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham B15 2TG, UK., Rosser EC; Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, UCL, London WC1E 6JF, UK.; Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCL Hospitals and Great Ormond Street Hospital, London WC1E 6JF, UK., Wedderburn LR; Infection, Immunity, and Inflammation Research and Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.; Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCL Hospitals and Great Ormond Street Hospital, London WC1E 6JF, UK.; NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK., Croft AP; Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.; Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Birmingham, Birmingham B15 2TT, UK.; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham B15 2TH, UK. |
| Corporate Authors: | MAPJAG Study Group, Multiomic Analysis of Paediatric Joint and Gut inflammation (MAPJAG) study group |
| Source: | Science translational medicine [Sci Transl Med] 2025 Jul 02; Vol. 17 (805), pp. eadt6050. Date of Electronic Publication: 2025 Jul 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 1946-6242 |
|---|---|
| DOI: | 10.1126/scitranslmed.adt6050 |
