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Polygenic Score Complements Family History and Lynch Syndrome Genes for Predicting Colorectal Cancer Risk.

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Title: Polygenic Score Complements Family History and Lynch Syndrome Genes for Predicting Colorectal Cancer Risk.
Authors: Helfand TY; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL., Wei J; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL., Mulford AJ; Genomic Health Initiative, Endeavor Health, Evanston, IL., Tran H; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL., Shi Z; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL., Wang CH; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL., Rifkin AS; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL., Ashworth A; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL., Zheng SL; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL., Helfand BT; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL.; University of Chicago Pritzker School of Medicine, Chicago, IL.; Department of Surgery, Endeavor Health, Evanston, IL., Dunnenberger HM; Neaman Center for Personalized Medicine, Endeavor Health, Evanston, IL., Duggan D; Translational Genomics Research Institute, TGen-an Affiliate of City of Hope, Phoenix, AZ., Hulick PJ; Neaman Center for Personalized Medicine, Endeavor Health, Evanston, IL., DePersia A; Neaman Center for Personalized Medicine, Endeavor Health, Evanston, IL., Sanders AR; Genomic Health Initiative, Endeavor Health, Evanston, IL.; University of Chicago Pritzker School of Medicine, Chicago, IL., Xu J; Program for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, IL.; University of Chicago Pritzker School of Medicine, Chicago, IL.; Department of Surgery, Endeavor Health, Evanston, IL.
Source: JCO precision oncology [JCO Precis Oncol] 2025 Jul; Vol. 9, pp. e2500081. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101705370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2473-4284 (Electronic) Linking ISSN: 24734284 NLM ISO Abbreviation: JCO Precis Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2473-4284
DOI:10.1200/PO-25-00081