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Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons.

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Title: Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons.
Authors: Edmonds KK; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Wilkinson ME; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Strebinger D; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Chen H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Lash B; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Schaefer CC; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Zhu S; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Liu D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Zilberzwige-Tal S; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Ladha A; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Walsh ML; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Frangieh CJ; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Vaz Reay NA; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Macrae RK; Howard Hughes Medical Institute, Cambridge, MA, USA.; Yang Tan Collective, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Wang X; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT, Cambridge, MA, 02142, USA., Zhang F; Howard Hughes Medical Institute, Cambridge, MA, USA. zhang@broadinstitute.org.; Yang Tan Collective, Cambridge, MA, USA. zhang@broadinstitute.org.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA. zhang@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. zhang@broadinstitute.org.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA. zhang@broadinstitute.org.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. zhang@broadinstitute.org.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. zhang@broadinstitute.org.
Source: Nature communications [Nat Commun] 2025 Jul 02; Vol. 16 (1), pp. 6079. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-61321-z