Pharmacometric and Digital Twin modeling for adaptive scheduling of combination therapy in advanced gastric cancer.

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Title: Pharmacometric and Digital Twin modeling for adaptive scheduling of combination therapy in advanced gastric cancer.
Authors: Prunella M; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., Altini N; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., D'Alessandro R; Laboratory of Experimental Oncology, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Schirizzi A; Laboratory of Experimental Oncology, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Ricci AD; Medical Oncology Unit, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Lotesoriere C; Medical Oncology Unit, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Scarabaggio P; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., Carli R; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., Dotoli M; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., Giannelli G; Scientific Direction, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Bevilacqua V; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy. Electronic address: vitoantonio.bevilacqua@poliba.it.
Source: Computer methods and programs in biomedicine [Comput Methods Programs Biomed] 2025 Oct; Vol. 270, pp. 108919. Date of Electronic Publication: 2025 Jun 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8506513 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7565 (Electronic) Linking ISSN: 01692607 NLM ISO Abbreviation: Comput Methods Programs Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-7565
DOI:10.1016/j.cmpb.2025.108919