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Pharmacometric and Digital Twin modeling for adaptive scheduling of combination therapy in advanced gastric cancer.

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Title: Pharmacometric and Digital Twin modeling for adaptive scheduling of combination therapy in advanced gastric cancer.
Authors: Prunella M; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., Altini N; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., D'Alessandro R; Laboratory of Experimental Oncology, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Schirizzi A; Laboratory of Experimental Oncology, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Ricci AD; Medical Oncology Unit, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Lotesoriere C; Medical Oncology Unit, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Scarabaggio P; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., Carli R; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., Dotoli M; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy., Giannelli G; Scientific Direction, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy., Bevilacqua V; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy. Electronic address: vitoantonio.bevilacqua@poliba.it.
Source: Computer methods and programs in biomedicine [Comput Methods Programs Biomed] 2025 Oct; Vol. 270, pp. 108919. Date of Electronic Publication: 2025 Jun 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8506513 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7565 (Electronic) Linking ISSN: 01692607 NLM ISO Abbreviation: Comput Methods Programs Biomed Subsets: MEDLINE
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  Data: Pharmacometric and Digital Twin modeling for adaptive scheduling of combination therapy in advanced gastric cancer.
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  Data: <searchLink fieldCode="AU" term="%22Prunella+M%22">Prunella M</searchLink>; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy.<br /><searchLink fieldCode="AU" term="%22Altini+N%22">Altini N</searchLink>; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy.<br /><searchLink fieldCode="AU" term="%22D'Alessandro+R%22">D'Alessandro R</searchLink>; Laboratory of Experimental Oncology, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy.<br /><searchLink fieldCode="AU" term="%22Schirizzi+A%22">Schirizzi A</searchLink>; Laboratory of Experimental Oncology, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy.<br /><searchLink fieldCode="AU" term="%22Ricci+AD%22">Ricci AD</searchLink>; Medical Oncology Unit, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy.<br /><searchLink fieldCode="AU" term="%22Lotesoriere+C%22">Lotesoriere C</searchLink>; Medical Oncology Unit, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy.<br /><searchLink fieldCode="AU" term="%22Scarabaggio+P%22">Scarabaggio P</searchLink>; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy.<br /><searchLink fieldCode="AU" term="%22Carli+R%22">Carli R</searchLink>; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy.<br /><searchLink fieldCode="AU" term="%22Dotoli+M%22">Dotoli M</searchLink>; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy.<br /><searchLink fieldCode="AU" term="%22Giannelli+G%22">Giannelli G</searchLink>; Scientific Direction, National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013, BA, Italy.<br /><searchLink fieldCode="AU" term="%22Bevilacqua+V%22">Bevilacqua V</searchLink>; Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, BA, 70126, Italy. Electronic address: vitoantonio.bevilacqua@poliba.it.
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  Data: <searchLink fieldCode="JN" term="%228506513%22">Computer methods and programs in biomedicine</searchLink> [Comput Methods Programs Biomed] 2025 Oct; Vol. 270, pp. 108919. <i>Date of Electronic Publication: </i>2025 Jun 28.
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              Text: 2025 Oct
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