Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery.

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Title: Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery.
Authors: Jafari L; Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Internal Medicine I, Justus Liebig University, Giessen, Germany., Wiedenroth CB; Department of Thoracic Surgery, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany., Kriechbaum SD; Department of Cardiology, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany.; Partner Site Rhein-Main, DZHK (German Center for Cardiovascular Research), Frankfurt am Main, Germany., Grün D; Department of Cardiology, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany.; Partner Site Rhein-Main, DZHK (German Center for Cardiovascular Research), Frankfurt am Main, Germany., Chelladurai P; Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany., Guenther S; Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Kuenne C; Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Späth AM; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health, Justus Liebig University, Giessen, Germany., Cherian AV; Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany., Troidl C; Department of Cardiology, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany.; Partner Site Rhein-Main, DZHK (German Center for Cardiovascular Research), Frankfurt am Main, Germany., Wilhelm J; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health, Justus Liebig University, Giessen, Germany., Keranov S; Department of Internal Medicine I, Justus Liebig University, Giessen, Germany., Keller T; Department of Cardiology, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany.; Partner Site Rhein-Main, DZHK (German Center for Cardiovascular Research), Frankfurt am Main, Germany., Kojonazarov B; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health, Justus Liebig University, Giessen, Germany., Schermuly RT; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health, Justus Liebig University, Giessen, Germany., Guth S; Department of Thoracic Surgery, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany., Dörr O; Department of Internal Medicine I, Justus Liebig University, Giessen, Germany., Nef H; Department of Internal Medicine I, Justus Liebig University, Giessen, Germany., Boehm M; Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford School of Medicine, Stanford University, Stanford, CA, USA.; Cardiovascular Institute, Stanford University, Stanford, CA, USA., Spiekerkoetter E; Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford School of Medicine, Stanford University, Stanford, CA, USA.; Cardiovascular Institute, Stanford University, Stanford, CA, USA., Leszek P; Heart Failure and Transplantology Department, Mechanical Circulatory Support and Transplant Department, National Institute of Cardiology, Warsaw, Poland., Varga ZV; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.; HCEMM-SU Cardiometabolic Immunology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.; Momentum-SU Cardio-oncology and Cardioimmunology Research Group, Budapest, Hungary., Ferdinandy P; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.; Center for Pharmacology and Drug Research & Development, Semmelweis University, Budapest, Hungary.; HUN-REN-SU System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.; Pharmahungary Group, Szeged, Hungary., Ghofrani HA; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany., Dorfmüller P; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health, Justus Liebig University, Giessen, Germany., Weißmann N; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany., Hamm CW; Department of Internal Medicine I, Justus Liebig University, Giessen, Germany.; Department of Cardiology, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany.; Partner Site Rhein-Main, DZHK (German Center for Cardiovascular Research), Frankfurt am Main, Germany., Mayer E; Department of Thoracic Surgery, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany., Seeger W; Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health, Justus Liebig University, Giessen, Germany., Liebetrau C; Department of Cardiology, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany. c.liebetrau@ccb.de.; Partner Site Rhein-Main, DZHK (German Center for Cardiovascular Research), Frankfurt am Main, Germany. c.liebetrau@ccb.de., Pullamsetti SS; Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. Soni.Pullamsetti@innere.med.uni-giessen.de.; Department of Internal Medicine II/V, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany. Soni.Pullamsetti@innere.med.uni-giessen.de.; Institute for Lung Health, Justus Liebig University, Giessen, Germany. Soni.Pullamsetti@innere.med.uni-giessen.de.
Source: Nature cardiovascular research [Nat Cardiovasc Res] 2025 Jul; Vol. 4 (7), pp. 857-875. Date of Electronic Publication: 2025 Jul 04.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2731-0590
DOI:10.1038/s44161-025-00672-8