Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine.

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Title: Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine.
Authors: Zhang J; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Chavez EC; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA., Winkler M; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Liu J; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University, Haining, China., Carver S; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Lin AE; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.; Lewis Sigler Center for Integrative Genomics, Princeton University, Princeton, NJ, USA., Biswas A; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.; Research Computing, Office of Information Technology, Princeton University, Princeton, NJ, USA., Tamura T; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.; Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan., Tseng A; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.; Department of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Wang D; Department of Chemistry, Princeton University, Princeton, NJ, USA., Benhamou A; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.; Department of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., O' Connell AK; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.; Department of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Matsuo M; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA., Norton JE; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA., Kenney D; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA., Adamson B; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.; Lewis Sigler Center for Integrative Genomics, Princeton University, Princeton, NJ, USA., Kleiner RE; Department of Chemistry, Princeton University, Princeton, NJ, USA., Burwitz B; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Crossland NA; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.; Department of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Douam F; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA., Ploss A; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. aploss@princeton.edu.
Source: Nature microbiology [Nat Microbiol] 2025 Aug; Vol. 10 (8), pp. 1902-1917. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2058-5276
DOI:10.1038/s41564-025-02047-y