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4'-O-methoxyethyl-2'-deoxy-uridine and cytidine ribonucleotides improve duplex stability, nuclease resistance, and elicit efficient knockdown of Bcl-2 expression.

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Title: 4'-O-methoxyethyl-2'-deoxy-uridine and cytidine ribonucleotides improve duplex stability, nuclease resistance, and elicit efficient knockdown of Bcl-2 expression.
Authors: Gangopadhyay S; Department of Chemistry, Indian Institute of Technology, Kharagpur, West Bengal 721302, India., Das G; Department of Chemistry, Indian Institute of Technology, Kharagpur, West Bengal 721302, India., Sharma SN; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Ghosh A; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Bagale SS; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India., Sinha S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Gore KR; Department of Chemistry, Indian Institute of Technology, Kharagpur, West Bengal 721302, India. Electronic address: kiran@chem.iitkgp.ac.in.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 01; Vol. 128, pp. 130329. Date of Electronic Publication: 2025 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3405
DOI:10.1016/j.bmcl.2025.130329