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Targeting modulation of the choroid plexus blood-CSF barrier and CSF hypersecretion via lipid nanoparticle-mediated co-delivery of siRNA and resveratrol.

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Title: Targeting modulation of the choroid plexus blood-CSF barrier and CSF hypersecretion via lipid nanoparticle-mediated co-delivery of siRNA and resveratrol.
Authors: Wang Q; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China., Xia X; Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, China., Zhang H; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China., Li Y; Research Core Facility of West China Hospital, Sichuan University, Chengdu, China., Zhu L; Institute of Thoracic Oncology, Sichuan University, Chengdu, China., Shi Y; Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, China., Tang Y; Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, China., Cheng J; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China., Hui X; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China., Gao H; Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, China. gaohuile@scu.edu.cn.
Source: Nature communications [Nat Commun] 2025 Jul 10; Vol. 16 (1), pp. 6389. Date of Electronic Publication: 2025 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-61543-1