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Naltrexone reduces bleomycin-induced lung fibrosis in rats by attenuating fibrosis, inflammation, oxidative stress, and extracellular matrix remodeling.

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Title: Naltrexone reduces bleomycin-induced lung fibrosis in rats by attenuating fibrosis, inflammation, oxidative stress, and extracellular matrix remodeling.
Authors: Mohammadi Hamaneh A; Experimental Medicine Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Nejati F; Experimental Medicine Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Teymoori Masuleh M; Experimental Medicine Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Manavi MA; Experimental Medicine Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran., Kazemzadeh H; Experimental Medicine Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran., Shafaroodi H; Experimental Medicine Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Hshafaroodi@gmail.com., Tavangar SM; Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Department of Intensive Care, Imam Khomeini Hospital Complex, TUMS, Tehran, Iran., Dehpour AR; Experimental Medicine Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Dehpour@yahoo.com.
Source: International immunopharmacology [Int Immunopharmacol] 2025 Sep 23; Vol. 162, pp. 115182. Date of Electronic Publication: 2025 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-1705
DOI:10.1016/j.intimp.2025.115182