A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma.

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Title: A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma.
Authors: Blass E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA., Keskin DB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA; Department of Computer Science, Metropolitan College, Boston University, Boston, MA 02215, USA; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, 2800 Lyngby, Denmark., Tu CR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Forman C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Vanasse A; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Sax HE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Shim B; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Chea V; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Kim N; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Carulli I; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Southard J; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Lyu H; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Lu W; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Rickles-Young M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Afeyan AB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA., Olive O; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Mehndiratta A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Greenslade H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Shetty K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Baginska J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Gomez Diaz I; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Nau A; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Gans A; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ranasinghe S; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Buchbinder EI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Sussman TA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Insco ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Yoon CH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02215, USA., Rodig SJ; Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA., Shukla SA; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Li S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Aster JC; Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA., Braun DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Section of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06511, USA; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06511, USA., Cibulskis C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA; Massachusetts General Hospital, Krantz Family Center for Cancer Research, Boston, MA 02114, USA., Neuberg DS; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Giobbie-Hurder A; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Livak KJ; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Fritsch EF; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Oliveira G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA., Simon JM; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Ott PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address: patrick_ott@dfci.harvard.edu.
Source: Cell [Cell] 2025 Sep 18; Vol. 188 (19), pp. 5125-5141.e27. Date of Electronic Publication: 2025 Jul 10.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2025.06.019