Key subunits of γ-secretase complex and breast cancer progression: biological function, regulation mode and therapeutic potential.

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Title: Key subunits of γ-secretase complex and breast cancer progression: biological function, regulation mode and therapeutic potential.
Authors: Xu R; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China., Yang X; Department of Endocrinology, General Hospital of Northern Theater Command, Shenyang 100015, China., Yao K; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China., Yang KF; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China., Hu LZ; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China., Zhan XY; School of Traditional Chinese Medicine, Shenyang Medical College, Shenyang 110034, China. Electronic address: xiangyizhan@symc.edu.cn., Zhou MS; Science and Experimental Research Center of Shenyang Medical College, Shenyang 110034, China; Shenyang Key Laboratory of Vascular Biology, Shenyang 110034, China. Electronic address: zhoums1963@163.com., Jia H; Shenyang Key Laboratory of Vascular Biology, Shenyang 110034, China; School of Traditional Chinese Medicine, Shenyang Medical College, Shenyang 110034, China. Electronic address: huijia412413@symc.edu.cn.
Source: Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2025 Sep; Vol. 1880 (4), pp. 189386. Date of Electronic Publication: 2025 Jul 11.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9806362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2561 (Electronic) Linking ISSN: 0304419X NLM ISO Abbreviation: Biochim Biophys Acta Rev Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-2561
DOI:10.1016/j.bbcan.2025.189386