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Prevention of extubation failure in neurocritical care patients with residual disorder of consciousness: the Brain-Injured Patients Extubation Readiness (BIPER) study protocol for a stepped-wedge cluster-randomised controlled trial.

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Title: Prevention of extubation failure in neurocritical care patients with residual disorder of consciousness: the Brain-Injured Patients Extubation Readiness (BIPER) study protocol for a stepped-wedge cluster-randomised controlled trial.
Authors: Chabanne R; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France rchabanne@chu-clermontferrand.fr., Godet T; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.; Department of Healthcare Simulation and NEURO-DOL, UMR 1107, INSERM, Université Clermont Auvergne Institut Sciences de la Vie Santé Agronomie Environnement, Clermont-Ferrand, France., Andanson B; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Borrel P; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Astier L; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Caumon E; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Bourguignon N; Department of Clinical Research and Innovation (DRCI), Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Laclautre L; Department of Clinical Research and Innovation (DRCI), Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Morand D; Department of Clinical Research and Innovation (DRCI), Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., De Jong A; Department of Anaesthesiology and Critical Care Medicine B (DAR B), Centre Hospitalier Universitaire de Montpellier, Montpellier, France.; PhyMed Exp, Université de Montpellier, INSERM U1046, Montpellier, France., Futier E; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.; iGReD, CNRS, INSERM, Université Clermont Auvergne, Clermont-Ferrand, France., Constantin JM; Department of Anesthesiology and Critical Care, Centre Hospitalier Universitaire Pitié Salpêtrière, Paris, France.; GRC 29, AP-HP, DMU DREAM, Sorbonne University, Paris, France., Pereira B; Biostatistics and Data Management Unit, Department of Clinical Research and Innovation, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Jabaudon M; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.; iGReD, CNRS, INSERM, Université Clermont Auvergne, Clermont-Ferrand, France.
Source: BMJ open [BMJ Open] 2025 Jul 13; Vol. 15 (7), pp. e104897. Date of Electronic Publication: 2025 Jul 13.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Prevention of extubation failure in neurocritical care patients with residual disorder of consciousness: the Brain-Injured Patients Extubation Readiness (BIPER) study protocol for a stepped-wedge cluster-randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Chabanne+R%22">Chabanne R</searchLink>; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France rchabanne@chu-clermontferrand.fr.<br /><searchLink fieldCode="AU" term="%22Godet+T%22">Godet T</searchLink>; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.; Department of Healthcare Simulation and NEURO-DOL, UMR 1107, INSERM, Université Clermont Auvergne Institut Sciences de la Vie Santé Agronomie Environnement, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Andanson+B%22">Andanson B</searchLink>; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Borrel+P%22">Borrel P</searchLink>; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Astier+L%22">Astier L</searchLink>; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Caumon+E%22">Caumon E</searchLink>; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Bourguignon+N%22">Bourguignon N</searchLink>; Department of Clinical Research and Innovation (DRCI), Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Laclautre+L%22">Laclautre L</searchLink>; Department of Clinical Research and Innovation (DRCI), Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Morand+D%22">Morand D</searchLink>; Department of Clinical Research and Innovation (DRCI), Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22De+Jong+A%22">De Jong A</searchLink>; Department of Anaesthesiology and Critical Care Medicine B (DAR B), Centre Hospitalier Universitaire de Montpellier, Montpellier, France.; PhyMed Exp, Université de Montpellier, INSERM U1046, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Futier+E%22">Futier E</searchLink>; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.; iGReD, CNRS, INSERM, Université Clermont Auvergne, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Constantin+JM%22">Constantin JM</searchLink>; Department of Anesthesiology and Critical Care, Centre Hospitalier Universitaire Pitié Salpêtrière, Paris, France.; GRC 29, AP-HP, DMU DREAM, Sorbonne University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Pereira+B%22">Pereira B</searchLink>; Biostatistics and Data Management Unit, Department of Clinical Research and Innovation, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Jabaudon+M%22">Jabaudon M</searchLink>; Department of Perioperative Medicine, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.; iGReD, CNRS, INSERM, Université Clermont Auvergne, Clermont-Ferrand, France.
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