Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice.

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Title: Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice.
Authors: Mazan-Mamczarz K; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Tsitsipatis D; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA., Childs BG; Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Carr AE; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Dos Santos CR; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA., Anerillas C; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Romero B; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE, USA., Gregg JM; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Henry-Smith C; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Okereke AN; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Michel M; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Munk R; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Martindale JL; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Piao Y; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Fan J; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Hernandez MO; Center for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA., Kedei N; Center for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA., Viacheslavov ML; Seqmatic LLC, Fremont, CA, USA., Wong MMF; Center for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA., Fedorova OV; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA., Batish M; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE, USA., De S; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Baker DJ; Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Gorospe M; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA. gorospem@grc.nia.nih.gov., Herman AB; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA. ali.herman@nih.gov.
Source: Nature aging [Nat Aging] 2025 Aug; Vol. 5 (8), pp. 1528-1547. Date of Electronic Publication: 2025 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-8465
DOI:10.1038/s43587-025-00889-z