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Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice.

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Title: Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice.
Authors: Mazan-Mamczarz K; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Tsitsipatis D; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA., Childs BG; Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Carr AE; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Dos Santos CR; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA., Anerillas C; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Romero B; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE, USA., Gregg JM; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Henry-Smith C; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Okereke AN; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Michel M; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Munk R; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Martindale JL; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Piao Y; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Fan J; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Hernandez MO; Center for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA., Kedei N; Center for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA., Viacheslavov ML; Seqmatic LLC, Fremont, CA, USA., Wong MMF; Center for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA., Fedorova OV; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA., Batish M; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE, USA., De S; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Baker DJ; Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Gorospe M; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA. gorospem@grc.nia.nih.gov., Herman AB; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA. ali.herman@nih.gov.
Source: Nature aging [Nat Aging] 2025 Aug; Vol. 5 (8), pp. 1528-1547. Date of Electronic Publication: 2025 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice.
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  Data: <searchLink fieldCode="AU" term="%22Mazan-Mamczarz+K%22">Mazan-Mamczarz K</searchLink>; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tsitsipatis+D%22">Tsitsipatis D</searchLink>; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Childs+BG%22">Childs BG</searchLink>; Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Carr+AE%22">Carr AE</searchLink>; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+CR%22">Dos Santos CR</searchLink>; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Anerillas+C%22">Anerillas C</searchLink>; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Romero+B%22">Romero B</searchLink>; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE, USA.<br /><searchLink fieldCode="AU" term="%22Gregg+JM%22">Gregg JM</searchLink>; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Henry-Smith+C%22">Henry-Smith C</searchLink>; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Okereke+AN%22">Okereke AN</searchLink>; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Michel+M%22">Michel M</searchLink>; 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Center for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kedei+N%22">Kedei N</searchLink>; Center for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Viacheslavov+ML%22">Viacheslavov ML</searchLink>; Seqmatic LLC, Fremont, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wong+MMF%22">Wong MMF</searchLink>; Center for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fedorova+OV%22">Fedorova OV</searchLink>; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Batish+M%22">Batish M</searchLink>; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE, USA.<br /><searchLink fieldCode="AU" term="%22De+S%22">De S</searchLink>; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Baker+DJ%22">Baker DJ</searchLink>; Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Gorospe+M%22">Gorospe M</searchLink>; Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA. gorospem@grc.nia.nih.gov.<br /><searchLink fieldCode="AU" term="%22Herman+AB%22">Herman AB</searchLink>; Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA. ali.herman@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2025 Aug; Vol. 5 (8), pp. 1528-1547. <i>Date of Electronic Publication: </i>2025 Jul 14.
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