Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study.
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| Title: | Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study. |
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| Authors: | Howey R; Research Software Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom.; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Adam J; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany., Adamski J; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany.; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Atabaki NN; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund, Sweden., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Chmura PJ; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., De Masi F; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., Fernandez-Tajes JJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Forgie IM; Diabetes Endocrinology and Reproductive Biology, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom., Franks PW; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund, Sweden.; Precision Healthcare University Research Institute, Queen Mary University of London, London, United Kingdom., Giordano GN; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund, Sweden., Haid M; Metabolomics and Proteomics Core, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen TH; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Medical Department, Zealand University Hospital, Køge, Denmark., Harms PP; Department of General Practice Medicine, Amsterdam UMC, Amsterdam, The Netherlands., Hattersley AT; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, United Kingdom.; Macleod Diabetes and Endocrine Centre, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom., Hong MG; SciLifeLab, Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden., Jacobsen UP; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jones AG; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, United Kingdom.; Macleod Diabetes and Endocrine Centre, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom., Koivula RW; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom., Kokkola T; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Mari A; Institute of Neuroscience, National Research Council, Rome, Italy., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., McDonald TJ; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, United Kingdom.; Academic Department of Clinical Biochemistry, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom., Musholt PB; Global Development, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany., Pavo I; Eli Lilly Regional Operations GmbH, Wien, Austria., Pearson ER; Diabetes Endocrinology and Reproductive Biology, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Metabolic Research, Herlev and Gentofte University Hospital, Copenhagen, Denmark., Ruetten H; Sanofi Partnering, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany., Rutters F; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands., Schwenk JM; SciLifeLab, Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden., Sharma S; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany., 't Hart LM; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden UMC, Leiden, The Netherlands., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Copenhagen, Denmark., Walker M; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Viñuela A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom., Cordell HJ; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. |
| Corporate Authors: | IMI DIRECT Consortium |
| Source: | PLoS genetics [PLoS Genet] 2025 Jul 15; Vol. 21 (7), pp. e1011776. Date of Electronic Publication: 2025 Jul 15 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1553-7404 |
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| DOI: | 10.1371/journal.pgen.1011776 |
