Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study.
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| Title: | Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study. |
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| Authors: | Howey R; Research Software Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom.; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Adam J; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany., Adamski J; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany.; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Atabaki NN; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund, Sweden., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Chmura PJ; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., De Masi F; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., Fernandez-Tajes JJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Forgie IM; Diabetes Endocrinology and Reproductive Biology, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom., Franks PW; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund, Sweden.; Precision Healthcare University Research Institute, Queen Mary University of London, London, United Kingdom., Giordano GN; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund, Sweden., Haid M; Metabolomics and Proteomics Core, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen TH; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Medical Department, Zealand University Hospital, Køge, Denmark., Harms PP; Department of General Practice Medicine, Amsterdam UMC, Amsterdam, The Netherlands., Hattersley AT; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, United Kingdom.; Macleod Diabetes and Endocrine Centre, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom., Hong MG; SciLifeLab, Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden., Jacobsen UP; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jones AG; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, United Kingdom.; Macleod Diabetes and Endocrine Centre, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom., Koivula RW; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom., Kokkola T; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Mari A; Institute of Neuroscience, National Research Council, Rome, Italy., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., McDonald TJ; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, United Kingdom.; Academic Department of Clinical Biochemistry, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom., Musholt PB; Global Development, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany., Pavo I; Eli Lilly Regional Operations GmbH, Wien, Austria., Pearson ER; Diabetes Endocrinology and Reproductive Biology, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Metabolic Research, Herlev and Gentofte University Hospital, Copenhagen, Denmark., Ruetten H; Sanofi Partnering, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany., Rutters F; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands., Schwenk JM; SciLifeLab, Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden., Sharma S; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany., 't Hart LM; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden UMC, Leiden, The Netherlands., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Copenhagen, Denmark., Walker M; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Viñuela A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom., Cordell HJ; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. |
| Corporate Authors: | IMI DIRECT Consortium |
| Source: | PLoS genetics [PLoS Genet] 2025 Jul 15; Vol. 21 (7), pp. e1011776. Date of Electronic Publication: 2025 Jul 15 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40663565 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Howey+R%22">Howey R</searchLink>; Research Software Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom.; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Adam+J%22">Adam J</searchLink>; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany.<br /><searchLink fieldCode="AU" term="%22Adamski+J%22">Adamski J</searchLink>; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany.; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Atabaki+NN%22">Atabaki NN</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Brunak+S%22">Brunak S</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Chmura+PJ%22">Chmura PJ</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22De+Masi+F%22">De Masi F</searchLink>; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Dermitzakis+ET%22">Dermitzakis ET</searchLink>; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fernandez-Tajes+JJ%22">Fernandez-Tajes JJ</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Forgie+IM%22">Forgie IM</searchLink>; Diabetes Endocrinology and Reproductive Biology, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Franks+PW%22">Franks PW</searchLink>; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund, Sweden.; Precision Healthcare University Research Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Giordano+GN%22">Giordano GN</searchLink>; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Haid+M%22">Haid M</searchLink>; Metabolomics and Proteomics Core, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany.<br /><searchLink fieldCode="AU" term="%22Hansen+T%22">Hansen T</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hansen+TH%22">Hansen TH</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Medical Department, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Harms+PP%22">Harms PP</searchLink>; Department of General Practice Medicine, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hattersley+AT%22">Hattersley AT</searchLink>; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, United Kingdom.; Macleod Diabetes and Endocrine Centre, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hong+MG%22">Hong MG</searchLink>; SciLifeLab, Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Jacobsen+UP%22">Jacobsen UP</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jones+AG%22">Jones AG</searchLink>; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, United Kingdom.; Macleod Diabetes and Endocrine Centre, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Koivula+RW%22">Koivula RW</searchLink>; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kokkola+T%22">Kokkola T</searchLink>; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Mahajan+A%22">Mahajan A</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mari+A%22">Mari A</searchLink>; Institute of Neuroscience, National Research Council, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22McCarthy+MI%22">McCarthy MI</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McDonald+TJ%22">McDonald TJ</searchLink>; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, United Kingdom.; Academic Department of Clinical Biochemistry, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Musholt+PB%22">Musholt PB</searchLink>; Global Development, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Pavo+I%22">Pavo I</searchLink>; Eli Lilly Regional Operations GmbH, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Pearson+ER%22">Pearson ER</searchLink>; Diabetes Endocrinology and Reproductive Biology, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pedersen+O%22">Pedersen O</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Metabolic Research, Herlev and Gentofte University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ruetten+H%22">Ruetten H</searchLink>; Sanofi Partnering, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Rutters+F%22">Rutters F</searchLink>; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schwenk+JM%22">Schwenk JM</searchLink>; SciLifeLab, Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; Research Unit of Molecular Epidemiology, Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum München, München, Germany.<br /><searchLink fieldCode="AU" term="%22't+Hart+LM%22">'t Hart LM</searchLink>; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden UMC, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vestergaard+H%22">Vestergaard H</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Walker+M%22">Walker M</searchLink>; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Viñuela+A%22">Viñuela A</searchLink>; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cordell+HJ%22">Cordell HJ</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22IMI+DIRECT+Consortium%22">IMI DIRECT Consortium</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101239074%22">PLoS genetics</searchLink> [PLoS Genet] 2025 Jul 15; Vol. 21 (7), pp. e1011776. <i>Date of Electronic Publication: </i>2025 Jul 15 (<i>Print Publication: </i>2025). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101239074 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1553-7404 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215537390%22">15537390 </searchLink><i>NLM ISO Abbreviation: </i>PLoS Genet <i>Subsets: </i>MEDLINE |
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