Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.

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Title: Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.
Authors: Leung YY; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Kuksa PP; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Carter L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Cifello J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Greenfest-Allen E; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Boateng L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Laub S; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Tulina N; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Moura S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Ramirez A; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Celis K; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Jin F; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Feng R; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Wang G; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., De Jager P; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Wang L; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Grant SFA; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA.; Divisions of Human Genetics and Endocrinology & Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Chesi A; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jun 26. Date of Electronic Publication: 2025 Jun 26.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.06.25.25328705