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Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.

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Title: Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.
Authors: Leung YY; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Kuksa PP; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Carter L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Cifello J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Greenfest-Allen E; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Boateng L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Laub S; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Tulina N; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Moura S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Ramirez A; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Celis K; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Jin F; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Feng R; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Wang G; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., De Jager P; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Wang L; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA., Grant SFA; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA.; Divisions of Human Genetics and Endocrinology & Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA., Chesi A; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jun 26. Date of Electronic Publication: 2025 Jun 26.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
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DbLabel: MEDLINE Ultimate
An: 40666338
AccessLevel: 2
PubType: Academic Journal
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  Data: Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.
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  Data: <searchLink fieldCode="AU" term="%22Leung+YY%22">Leung YY</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Kuksa+PP%22">Kuksa PP</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Carter+L%22">Carter L</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Cifello+J%22">Cifello J</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Greenfest-Allen+E%22">Greenfest-Allen E</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Valladares+O%22">Valladares O</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Boateng+L%22">Boateng L</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Laub+S%22">Laub S</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Tulina+N%22">Tulina N</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Moura+S%22">Moura S</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Ramirez+A%22">Ramirez A</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Celis+K%22">Celis K</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Jin+F%22">Jin F</searchLink>; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Feng+R%22">Feng R</searchLink>; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+P%22">De Jager P</searchLink>; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vance+JM%22">Vance JM</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Grant+SFA%22">Grant SFA</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA.; Divisions of Human Genetics and Endocrinology & Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Schellenberg+GD%22">Schellenberg GD</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Chesi+A%22">Chesi A</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA.<br /><searchLink fieldCode="AU" term="%22Wang+LS%22">Wang LS</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA.
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2025 Jun 26. <i>Date of Electronic Publication: </i>2025 Jun 26.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1101/2025.06.25.25328705
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        Text: English
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      – TitleFull: Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.
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