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Complement is activated in patients with acute chest syndrome caused by sickle cell disease and represents a therapeutic target.

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Title: Complement is activated in patients with acute chest syndrome caused by sickle cell disease and represents a therapeutic target.
Authors: Chonat S; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Jones JA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Patel SR; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Briones WM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Schoettler ML; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Maarouf M; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Jeffers LA; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Adisa O; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA., Tan F; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Fields E; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Sterling MS; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Jajosky RP; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Verkerke H; Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA., Graciaa SH; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA., Foppiani EM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Fasano RM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA., Zerra PE; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA., Qiu Y; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Wallace H. Coulter Department of Biomedical Engineering, Atlanta, GA 30322, USA., Arthur CM; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Lam WA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Wallace H. Coulter Department of Biomedical Engineering, Atlanta, GA 30322, USA., Ofori-Acquah SF; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Medicine, Pittsburgh Heart Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA., Koval M; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Joiner CH; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Archer DR; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Stowell SR; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Jul 16; Vol. 17 (807), pp. eadl4922. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adl4922