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Complement is activated in patients with acute chest syndrome caused by sickle cell disease and represents a therapeutic target.

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Title: Complement is activated in patients with acute chest syndrome caused by sickle cell disease and represents a therapeutic target.
Authors: Chonat S; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Jones JA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Patel SR; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Briones WM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Schoettler ML; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Maarouf M; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Jeffers LA; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Adisa O; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA., Tan F; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Fields E; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Sterling MS; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Jajosky RP; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Verkerke H; Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA., Graciaa SH; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA., Foppiani EM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Fasano RM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA., Zerra PE; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA., Qiu Y; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Wallace H. Coulter Department of Biomedical Engineering, Atlanta, GA 30322, USA., Arthur CM; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Lam WA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Wallace H. Coulter Department of Biomedical Engineering, Atlanta, GA 30322, USA., Ofori-Acquah SF; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Medicine, Pittsburgh Heart Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA., Koval M; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Joiner CH; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Archer DR; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Stowell SR; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Jul 16; Vol. 17 (807), pp. eadl4922. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Complement is activated in patients with acute chest syndrome caused by sickle cell disease and represents a therapeutic target.
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  Data: <searchLink fieldCode="AU" term="%22Chonat+S%22">Chonat S</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Jones+JA%22">Jones JA</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Patel+SR%22">Patel SR</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Briones+WM%22">Briones WM</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Schoettler+ML%22">Schoettler ML</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Maarouf+M%22">Maarouf M</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Jeffers+LA%22">Jeffers LA</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Adisa+O%22">Adisa O</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA.<br /><searchLink fieldCode="AU" term="%22Tan+F%22">Tan F</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Fields+E%22">Fields E</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Sterling+MS%22">Sterling MS</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Jajosky+RP%22">Jajosky RP</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Verkerke+H%22">Verkerke H</searchLink>; Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Graciaa+SH%22">Graciaa SH</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Foppiani+EM%22">Foppiani EM</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Fasano+RM%22">Fasano RM</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Zerra+PE%22">Zerra PE</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+Y%22">Qiu Y</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Wallace H. Coulter Department of Biomedical Engineering, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Arthur+CM%22">Arthur CM</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lam+WA%22">Lam WA</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Wallace H. Coulter Department of Biomedical Engineering, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Ofori-Acquah+SF%22">Ofori-Acquah SF</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Medicine, Pittsburgh Heart Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Koval+M%22">Koval M</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Joiner+CH%22">Joiner CH</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Archer+DR%22">Archer DR</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Stowell+SR%22">Stowell SR</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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