Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.

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Title: Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex.
Authors: Ossenkoppele R; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. r.ossenkoppele@amsterdamumc.nl.; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands. r.ossenkoppele@amsterdamumc.nl.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands. r.ossenkoppele@amsterdamumc.nl., Coomans EM; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands., Apostolova LG; Indiana University School of Medicine, Indianapolis, IN, USA., Baker SL; Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Barthel H; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany., Beach TG; Banner Sun Health Research Institute, Sun City, AZ, USA., Benzinger TLS; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington, Washington University School of Medicine, St. Louis, MO, USA., Betthauser T; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA., Bischof GN; Faculty of Medicine, University of Cologne and Department of Nuclear Medicine University Hospital Cologne, Cologne, Germany.; Molecular Organization of the Brain, Institute for Neurosciences and Medicine, Jülich, Germany., Bottlaender M; Université Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS, INSERM, Orsay, France.; UNIACT, Neurospin, CEA, Gif-sur-Yvette, France., Bourgeat P; Australian eHealth Research Centre, CSIRO, Melbourne, Victoria, Australia., den Braber A; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Brendel M; Department of Nuclear Medicine, LMU Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Brickman AM; Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Cash DM; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute at University College London, London, UK., Carrillo MC; Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA., Coath W; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Christian BT; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Dickerson BC; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Thinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA.; Massachusetts Alzheimer's Disease Research Center, Boston, MA, USA., Dore V; Australian eHealth Research Centre, CSIRO, Melbourne, Victoria, Australia.; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia., Drzezga A; Faculty of Medicine, University of Cologne and Department of Nuclear Medicine University Hospital Cologne, Cologne, Germany.; Molecular Organization of the Brain, Institute for Neurosciences and Medicine, Jülich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Feizpour A; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia., van der Flier WM; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Epidemiology and Biostatistics, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands., Franzmeier N; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Institute of Neuroscience and Physiology, Gothenburg, Sweden., Frisoni GB; Memory Clinic, Geneva University Hospitals, Geneva, Switzerland., Garibotto V; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.; Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland.; CIBM Center for Biomedical Imaging, Geneva, Switzerland., van de Giessen E; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Radiology & Nuclear Medicine, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands., Domingo-Gispert J; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain., Gnoerich J; Department of Nuclear Medicine, LMU Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany., Gu Y; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Guan Y; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Hanseeuw BJ; Institute of Neuroscience, UCLouvain, Brussels, Belgium.; Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.; Gordon Center for Medical Imaging, Department of Radiology, Mass General Brigham, Boston, MA, USA., Harrison TM; Department of Neuroscience, University of California Berkeley, Berkeley, CA, USA., Jack CR; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Jaeger E; Department of Nuclear Medicine, University of Cologne, University Hospital of Cologne, Cologne, Germany., Jagust WJ; Department of Neuroscience, University of California Berkeley, Berkeley, CA, USA., Jansen WJ; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., La Joie R; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Johnson KA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Johnson SC; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Kennedy IA; Eli Lilly and Company, Indianapolis, IN, USA., Kim JP; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., van Laere K; Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium., Lagarde J; Université Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS, INSERM, Orsay, France.; Department of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte Anne, Paris, France., Lao P; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, NY, USA., Luchsinger JA; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, NY, USA., Kern S; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuropsychiatry, Sahlgrenska University Hospital, Gothenburg, Sweden., Kreisl WC; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Malotaux V; Institute of Neuroscience, UCLouvain, Brussels, Belgium., Malpetti M; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Manly JJ; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Mao X; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden., Messerschmidt K; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany., Minguillon C; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Mormino EM; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., O'Brien JT; Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK., Palmqvist S; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Peretti DE; Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Pijnenburg YAL; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands., Pontecorvo MJ; Eli Lilly and Company, Indianapolis, IN, USA., Poirier J; Douglas Mental Health University Institute, Centre for Studies on the Prevention of Alzheimer's Disease (StoP-AD), Montréal, Québec, Canada.; Department of Psychiatry, McGill University, Montréal, Québec, Canada., Rabinovici GD; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.; Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA., Rahmouni N; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montréal, Québec, Canada., Risacher SL; Indiana University, Indianapolis, IN, USA., Rosa-Neto P; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montréal, Québec, Canada., Rosen H; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Rowe CC; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia., Rowe JB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK., Rullmann M; Clinic for Cognitive Neurology, University Hospital of Leipzig and Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Salman Y; Institute of Neuroscience, UCLouvain, Brussels, Belgium., Sarazin M; Université Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS, INSERM, Orsay, France.; Department of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte-Anne, Paris, France., Saykin AJ; Indiana University, Indianapolis, IN, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Department of Pathology, Rush University Medical Center, Chicago, IL, USA., Schöll M; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.; Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK., Schott JM; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute, London, UK., Seo SW; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Serrano GE; Banner Sun Health Research Institute, Sun City, AZ, USA., Shcherbinin S; Eli Lilly and Company, Indianapolis, IN, USA., Shekari M; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Skoog I; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden., Smith R; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Sperling RA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Spruyt L; Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium., Stomrud E; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Strandberg O; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden., Therriault J; Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montréal, Québec, Canada., Xie F; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Neurology Service, University Hospital Leuven, Leuven, Belgium., Villemagne VL; Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Villeneuve S; Douglas Mental Health University Institute, Centre for Studies on the Prevention of Alzheimer's Disease (StoP-AD), Montréal, Québec, Canada.; Department of Psychiatry, McGill University, Montréal, Québec, Canada., Visser PJ; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Vossler H; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Young CB; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Groot C; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC; location VUmc, Amsterdam, The Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, The Netherlands., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. oskar.hansson@med.lu.se.; Memory Clinic, Skåne University Hospital, Malmö, Sweden. oskar.hansson@med.lu.se.
Corporate Authors: Mayo Clinic Study on Aging, PREVENT-AD Research Group
Source: Nature neuroscience [Nat Neurosci] 2025 Aug; Vol. 28 (8), pp. 1610-1621. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1726
DOI:10.1038/s41593-025-02000-6